Evidence map›Paper›PMID 40721629›Full record

ArticleScientific reports2025

Protective effects of liraglutide on hypercholesterolemia-associated atherosclerosis involve attenuation of endothelial-monocyte adhesion through down-regulating the LOX-1/NF-κB signaling pathway.

Aiping Wu, Ying Wu, Meiyan Song, Wen Chen, Kaizu Xu, Meifang Wu, Liming Lin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Aiping WuDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China.
Ying WuDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China.
Meiyan SongDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China.
Wen ChenDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China.
Kaizu XuDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China.
Meifang WuDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China. 626549128@qq.com.
Liming LinDepartment of Cardiology, Affiliated Hospital of Putian University, School of Clinical Medicine, Fujian Medical University, Putian, 351100, Fujian, China. 2533358160@qq.com.

Funding

Fujian Provincial Health Technology Project 2022CXA057National Natural Science Foundation of China 8180027Natural Science Foundation of Fujian Province 2021J01122508Natural Science Foundation of Fujian Province 2022J011433Natural Science Foundation of Fujian Province 2022J011438
6 · The paper itself

Abstract

To investigate the impact of liraglutide (LIR) on experimental hypercholesterolemia-associated atherosclerosis and endothelial-monocyte adhesion, as well as elucidate the involvement of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1)/NF-κB signaling pathway in this process. High-fat diet-fed ApoE

Indexed as

AtherosclerosisEndothelial CellsHypercholesterolemiaLiraglutideMonocytesNF-kappa BScavenger Receptors, Class ESignal TransductionAnimalsCell AdhesionDiet, High-FatDown-RegulationMaleMiceMice, Inbred C57BLLiraglutideNF-kappa BOlr1 protein, mouseScavenger Receptors, Class EAdhesionEndothelial cellsLectin-like ox-LDL receptor 1LiraglutideNuclear factor-κB

Identifiers

PMID40721629
PMCPMC12304136

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.