ArticleNature neuroscience2025
Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- The multiple scales of astrocytic functional units.Nature neuroscience · 2026Review
- Astrocyte Functional Heterogeneity in Multiple Sclerosis.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum.Nature communications · 2026Article
- A transcriptomic atlas of astrocyte heterogeneity across space and time in mouse and marmoset.Neuron · 2025Article
- Review
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16 authors.
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Abstract
Astrocyte specification during development is influenced by both intrinsic and extrinsic factors, but the precise contribution of each remains poorly understood. Here we show that mouse septal astrocytes derived from Nkx2.1- and Zic4-expressing progenitor zones are primarily allocated into the medial septal and lateral septal nuclei, respectively. Astrocytes in these areas exhibit distinctive molecular and morphological features. Using single-nucleus RNA sequencing, we traced the developmental trajectories of cells in the septum and found that neurons and astrocytes undergo region-specific and developmental-stage-specific local cell-cell interactions. Expression of the morphogens sonic hedgehog and fibroblast growth factors by medial septal and lateral septal neurons, respectively, promote the specification of astrocytes in each region. Finally, heterotopic cell transplantation studies showed that septal astrocyte specification depends on the local microenvironment, regardless of developmental origin. Our data highlight the importance of the local environment in determining astrocyte functional specialization.
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