Evidence map›Paper›PMID 40721691›Full record

ArticleCell biochemistry and biophysics2025

Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway.

Ming Xiang, Xiangdong Lin, Haiying Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ming XiangProvincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Xiangdong LinDepartment of Endocrinology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China. 275205959@qq.com.
Haiying ChenDepartment of Nephrology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China. chenhaiying@hnucm.edu.cn.

Funding

Natural Science Foundation of Hunan Province 2024JJ9440Research Project of Education Department of Hunan Province 23B0359Research Project of Traditional Chinese Medicine Administration of Hunan Province C2023021Undergraduate Research and Innovation Fund 2023BKS159,2023BKS164University-level project of Hunan University of Chinese Medicine Z2023XJYB16
6 · The paper itself

Abstract

Coronary heart disease (CHD) is a disease caused by organic and functional coronary artery stenosis, resulting in a reduced oxygen supply to the heart. This study aimed to investigate the mechanism via which Luteolin regulates the Sirt1/Nrf2 pathway to inhibit ferroptosis in human umbilical vein endothelial cells (HUVEC) associated with CHD. An ox-LDL-induced HUVEC cell model with Sirt1 silencing and Luteolin treatment was established. The silencing efficiency of Sirt1 was validated using quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot analysis. The results of molecular docking and DARTS experiments showed that Luteolin could effectively bind Sirt1. Subsequently, we measured the expression of Nrf2 and Sirt1, cell viability, MDA, GSH, Fe

Indexed as

FerroptosisLuteolinNF-E2-Related Factor 2Signal TransductionSirtuin 1Cell MovementCell SurvivalHumansHuman Umbilical Vein Endothelial CellsLipoproteins, LDLMolecular Docking SimulationReactive Oxygen SpeciesLipoproteins, LDLLuteolinNFE2L2 protein, humanNF-E2-Related Factor 2oxidized low density lipoproteinReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1Coronary heart diseaseFerroptosisLuteolinSirt1

Identifiers

PMID40721691

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.