Evidence map›Paper›PMID 40721783›Full record

Trial reportBMC medicine2025

Healthy lifestyle factors and recurrent cardiovascular events in patients with OSA: the SAVE study.

Shoujiang You, Danni Zheng, Kelly A Loffler, R Doug McEvoy, Qiang Li, Yuanming Luo, Ferran Barbé, Qiong Ou, Rui Chen, Chun-Feng Liu and 6 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shoujiang You *Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of SooChow University, Suzhou, China.
Danni Zheng *The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Missenden Road, PO Box M201, Sydney, NSW, 2050, Australia.
Kelly A LofflerFlinders Health and Medical Research Institute, College of Medicine and Public Health,, Flinders University, Adelaide, Australia.
R Doug McEvoyFlinders Health and Medical Research Institute, College of Medicine and Public Health,, Flinders University, Adelaide, Australia.
Qiang LiThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Missenden Road, PO Box M201, Sydney, NSW, 2050, Australia.
Yuanming LuoThe First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou, People's Republic of China.
Ferran BarbéRespiratory Department, Centro de Investigacio´n Biome´dica en Red de Enfermedades Respiratorias, Institutde Recerca Biome`dica de Lleida, Madrid, Spain.
Qiong OuSleep Center, Respiratory and Critical Medical Department, Guangdong Geriatric Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510000, People's Republic of China.
Rui ChenDepartment of Respiratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chun-Feng LiuDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of SooChow University, Suzhou, China.
Yongjun CaoDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of SooChow University, Suzhou, China.
Xia WangThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Missenden Road, PO Box M201, Sydney, NSW, 2050, Australia.
Geraldo Lorenzi-FilhoInstituto do Coracao (Incor) and Hospital Universitario, Sao Paulo, Brazil.
Manjari TripathiNeurology Department, All India Institute of Medical Sciences, Delhi, India.
Craig S AndersonThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Missenden Road, PO Box M201, Sydney, NSW, 2050, Australia. canderson@georgeinstitute.org.au.
SAVE Investigators

Funding

Fisher & Paykel Healthcare, the Australasian Sleep Trials Network 343020Fondo de Investigaciones Sanitarias 13/02053the National Health and Medical Research Council (NHMRC) of Australia 1006501 and 1060078the Spanish Respiratory Society 105-2011
6 · The paper itself

Abstract

backgroundThe extent to which healthy lifestyle factors influence recurrent cardiovascular events in obstructive sleep apnea (OSA) patients is uncertain. To evaluate the association between adherence to baseline healthy lifestyle and the risk of recurrent cardiovascular events in OSA patients.

methodsPost hoc analyses of the Sleep Apnea Cardiovascular Endpoints (SAVE) study involving participants with moderate-to-severe OSA and established cardiovascular disease (CVD) who were randomized to continuous positive airway pressure (CPAP) plus usual care or usual care alone. We assigned a score ranging from 0 to 4 for each participant, based on the number of criteria met for the baseline health lifestyle factors of non-smoking, moderate-to-vigorous physical activity, ideal waist/hip ratio, and low-to-moderate alcohol consumption.

resultsIn total, 2659 OSA patients with established CVD were included. The adjusted hazard ratios for participants with ≥ 2 healthy lifestyle factors compared with none were 0.64 (95% confidence interval [CI] 0.50-0.84) for composite cardiovascular events, 0.46 (0.28-0.74) for stroke, 0.65 (0.45-0.96) for hospitalization for unstable angina, 0.35 (0.19-0.63) for all-cause mortality, and 0.36 (0.16-0.79) for CVD death during a mean follow-up of 3.7 years. Each increment in healthy lifestyle factor score was associated with reduced risk of composite and separate cardiovascular events. A trend was found showing greater CPAP treatment benefit in those with more baseline healthy lifestyle for myocardial infarction and all-cause mortality; however, it did not reach statistical significance.

conclusionsGreater adherence to an overall baseline healthy lifestyle is significantly associated with a lower risk of recurrent composite cardiovascular events in OSA patients with established CVD.

Indexed as

Cardiovascular DiseasesHealthy LifestyleSleep Apnea, ObstructiveAgedContinuous Positive Airway PressureFemaleHumansMaleMiddle AgedRecurrenceRisk FactorsHealthy lifestyle factorsObstructive sleep apneaPredictRecurrent cardiovascular eventsSAVE

Identifiers

PMID40721783
PMCPMC12306100

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.