Evidence map›Paper›PMID 40721843›Full record

SynthesisAdvances in rheumatology (London, England)2025

Effects of interventions with resistance exercises on muscle strength, physical disability, and quality of life in systemic sclerosis patients: a systematic review with meta-analysis.

André Luiz Silveira Mallmann, Daniel Nóbrega de Moraes, Lucas Denardi Dória, Leonardo Peterson Dos Santos, Stephanie Pilotti, Mayra Angélica de Souza Antunes, Laura Fontana Steinmetz, Thauan Júnior Santos de Souza, Vanessa Hax, Jerri Luiz Ribeiro and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Advances in rheumatology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

André Luiz Silveira MallmannPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-4994-098X
Daniel Nóbrega de MoraesPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. danielnobregademoraes@gmail.com.ORCID 0000-0001-7155-7808
Lucas Denardi DóriaPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-9595-5875
Leonardo Peterson Dos SantosPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0001-8623-5596
Stephanie PilottiPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-1474-6220
Mayra Angélica de Souza AntunesHospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-5096-1868
Laura Fontana SteinmetzHospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-2209-2319
Thauan Júnior Santos de SouzaHospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0003-2236-8343
Vanessa HaxHospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0003-3240-7174
Jerri Luiz RibeiroPostgraduate Program in Human Movement Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID 0000-0001-5194-5950
Ricardo Machado XavierPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0001-6570-4533
Rafael Mendonça da Silva ChakrPostgraduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-8677-2479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSystemic sclerosis (SSc) often leads to decreased muscle strength and mass, impairing physical performance and causing disability. Interventions with resistance exercise (RE) is an effective non-pharmacological approach to mitigate these issues. This systematic review aims to evaluate the effects of interventions with RE on muscle strength, muscle mass, physical performance, physical disability, and quality of life (QOL) in SSc patients, as well as to assess its adherence and safety.

methodsA systematic review and meta-analysis were conducted based on a PICOS framework: Patient = Systemic Sclerosis; Intervention = Resistance exercise; Study design = Randomized clinical trials. Searches were performed across MEDLINE (PubMed), PMC, Web of Science, Cochrane Library, LILACS, and EMBASE up to January 2025.

resultsTen randomized clinical trials, including 422 participants (~85% female), were eligible for analysis. Participants' ages ranged from 42 to 64 years, with body mass indices between 22.5 and 28.0 kg/m

conclusionInterventions with RE benefits muscle strength, physical function, and QOL in SSc patients, though optimal protocols and adherence strategies need further investigation. More robust studies are required to refine training methods and enhance clinical trial designs.

Indexed as

Muscle StrengthQuality of LifeResistance TrainingScleroderma, SystemicDisability EvaluationFemaleHumansMiddle AgedPhysical Functional PerformanceRandomized Controlled Trials as TopicMuscle strengthOccupational therapyPhysical disabilityPhysical rehabilitationQuality of lifeResistance trainingScleroderma

Identifiers

PMID40721843
PMCPMC13488637

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.