Evidence map›Paper›PMID 40721923›Full record

ArticleJournal of cancer survivorship : research and practice2025

The impact of cancer diagnosis on functional decline in adults aged 50 and older: the US Health and Retirement Study.

Gina E Nam, Elizabeth Rose Mayeda, Yancen Pan, Eleanor Hayes-Larson, L Paloma Rojas-Saunero, Hua Zhou, Jian Yu Rao, Zuo-Feng Zhang

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Gina E NamDepartment of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA, 90095-1772, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA, 90095-1772, USA.
Yancen PanDepartment of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA, 90095-1772, USA.
Eleanor Hayes-LarsonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
L Paloma Rojas-SauneroDepartment of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA, 90095-1772, USA.
Hua ZhouDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Jian Yu RaoDepartment of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA, 90095-1772, USA.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, 71-225 CHS, 650 Charles E. Young Drive South, Box 951772, Los Angeles, CA, 90095-1772, USA. zfzhang@ucla.edu.

Funding

UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Genomics, GPUs, and Next Generation Computational StatisticsR01HG006139 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOBEL, ERIC · 2011 to 2023
$5.1M
Modeling, Inference, and Optimization for Genomic and Biomedical Big DataR35GM141798 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LANGE, KENNETH L · 2021 to 2025
$2.7M
The inverse association between cancer and Alzheimers disease: comparing spurious and causal explanations to illuminate the causes of Alzheimers diseaseRF1AG059872 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLYMOUR, MEDELLENA MARIA · 2018 to 2021
$1.9M
Effects of lifecourse traumatic stress on late-life cognitive decline, dementia, and neuroimaging biomarkersR00AG075317 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Eleanor Louise Hayes-Larson · 2024 to 2026
$742k
Effects of lifecourse traumatic stress on late-life cognitive decline, dementia, and neuroimaging biomarkersK99AG075317 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAYES-LARSON, ELEANOR LOUISE · 2022 to 2023
$241k
National Institutes of Health, United States R35GM141798National Science Foundation DSM-2054253NCI NIH HHS T32 CA009142NCI NIH HHS T32CA009142NHGRI NIH HHS R01 HG006139NIA NIH HHS K99 AG075317NIA NIH HHS R00 AG075317NIA NIH HHS RF1 AG059872NIA NIH HHS RF1AG059872NIGMS NIH HHS R35 GM141798
6 · The paper itself

Abstract

purposeWe conducted a longitudinal secondary data analysis to estimate long-term functional limitation trajectories of adults over 50 with cancer compared to cancer-free individuals.

methodsUsing the Health and Retirement Study (1998-2020), we followed adults over 50 without cancer history. Incident cancer was self-reported or proxy reported. Functional decline was assessed using self-reported independence in six domains, including instrumental activities of daily living (IADL), activities of daily living (ADL), mobility, large muscle, gross motor, and fine motor skills. We employed linear probability models with repeated measures to estimate independence probabilities.

resultsAmong 15,972 participants (mean [SD] age, 66.1 [9.9] years), 23.1% reported cancer during follow-up. Before diagnosis, individuals with cancer had a 1.3% lower probability of IADL independence compared to cancer-free individuals (95% CI =  - 1.9, - 0.7). After diagnosis, cancer survivors experienced a sharp 6% drop in IADL independence, resulting in a 3.4% lower probability than in those without cancer (- 4.6, - 2.2). The annual rate of IADL decline after diagnosis was slower in cancer survivors compared to those without cancer (- 0.9% vs. - 1.3%). Similar patterns were observed for ADL. The greatest immediate reduction was in the gross motor domain with a decline of 8.6% (- 10.4, - 6.8).

conclusionsCancer survivors experienced rapid functional decline at diagnosis, possibly attributed to active treatment. Following diagnosis, cancer survivors had a more gradual loss in functional independence compared to cancer-free individuals. IMPLICATIONS FOR CANCER SURVIVORS: Findings underscore the importance of proactive, tailored interventions to support functional independence in older cancer survivors, particularly around diagnosis.

Indexed as

ADLCancerFunctional declineIADLOlder adultsOlder cancer survivors

Identifiers

PMID40721923
PMCPMC13131248

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.