Evidence map›Paper›PMID 40722246›Full record

ArticleJournal of Zhejiang University. Science. B2025

Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys.

Xin Lv, Jie Liu, Shuo Ma, Yuhan Wang, Yixin Pan, Xian Qiu, Yu Cao, Bomin Sun, Shikun Zhan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin LvCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jie LiuCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shuo MaCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yuhan WangCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yixin PanCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xian QiuDepartment of Nursing, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai 200025, China.
Yu CaoShandong Mental Health Center, Jinan 250014, China.
Bomin SunCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. shikun_zhan@hotmail.com, sbm11224@rjh.com.cn.
Shikun ZhanCenter of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. shikun_zhan@hotmail.com.

Funding

the 2024 Shanghai Ruijin Hospital Nursing Research Fund RJHK-2024-001the National Natural Science Foundation of China 82271515the Nursing Development Program of Shanghai Jiao Tong University School of Medicine SJTUHLXK2022the Scientific and Technological Innovation Action Plan of Shanghai KY20211478the Shanghai Municipal Science and Technology Major Project 2021SHZDZXthe Shanghai Nursing Association Funding 2024MS-B13the SJTU Trans-Med Awards Research 2019015
6 · The paper itself

Abstract

Abuse of amphetamine-based stimulants is a primary public health concern. Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants. However, the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure (AME) on sleep homeostasis remain to be explored. This study employed non-human primates and electroencephalogram (EEG) sleep staging to evaluate the influence of AME on neural oscillations. The primary focus was on alterations in spindles, delta oscillations, and slow oscillations (SOs) and their interactions as conduits through which AME influences sleep stability. AME predominantly diminishes sleep-spindle waves in the non-rapid eye movement 2 (NREM2) stage, and impacts SOs and delta waves differentially. Furthermore, the competitive relationships between SO/delta waves nesting with sleep spindles were selectively strengthened by methamphetamine. Complexity analysis also revealed that the SO-nested spindles had lost their ability to maintain sleep depth and stability. In summary, this finding could be one of the intrinsic electrophysiological mechanisms by which AME disrupted sleep homeostasis.

Indexed as

Central Nervous System StimulantsDelta RhythmMethamphetamineSleepAnimalsElectroencephalographyMaleSleep StagesCentral Nervous System StimulantsMethamphetamineAddictionAmphetamineDelta oscillationElectroencephalogram (EEG)Sleep stageSlow oscillation (SO)

Identifiers

PMID40722246
PMCPMC12303792

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.