The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study.

Yiqun Hu, Guang Yang, Zhenhan Deng, Shengwu Yang, Yusheng Li, Wenfeng Xiao, Bangbao Lu, Xiongbai Zhu

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yiqun HuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China.

Guang YangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China.

Zhenhan DengDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID 0000-0003-0522-8269

Shengwu YangDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Yusheng LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China.

Wenfeng XiaoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China.

Bangbao LuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha 410000, China.

Xiongbai ZhuDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID 0009-0009-2276-4320

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the central mechanisms of fibromyalgia have gained attention, the causal effects between brain networks and fibromyalgia remain unclear. Two-sample Mendelian randomization and Linkage Disequilibrium Score Regression were performed to investigate the relationship between 191 rsfMRI traits and 8 fibromyalgia-related traits. A total of 4 rsfMRI traits were genetically correlated with trouble falling asleep, 11 with back pain for 3+ months, 16 with pain all over the body, 14 with insomnia, 5 with fibromyalgia, 4 with fibromyalgia, and 3 with malaise and fatigue. Pheno801 has significant causal effects on malaise and fatigue (OR = 1.0022,

Indexed as

brain functional networksfibromyalgiagenetic correlationsmendelian randomizationresting-state functional MRI

Identifiers

PMID40722384

DOI10.3390/bioengineering12070692

PMCPMC12292968

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.