Evidence map›Paper›PMID 40723170›Full record

ArticleCancers2025

Integrating

Joanna M Wybranska, Lorenz Pieper, Christian Wybranski, Philipp Genseke, Jan Wuestemann, Julian Varghese, Michael C Kreissl, Jakub Mitura

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joanna M WybranskaDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0009-0005-3473-9342
Lorenz PieperDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0009-0002-6909-1070
Christian WybranskiDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0003-3324-6114
Philipp GensekeDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0002-8866-3655
Jan WuestemannDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0009-0008-6277-7874
Julian VargheseInstitut für Medical Data Science, Medical Faculty, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0002-7206-3719
Michael C KreisslDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0001-5905-6015
Jakub MituraDivision of Nuclear Medicine, Department of Radiology & Nuclear Medicine, Faculty of Medicine, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany.ORCID 0000-0003-1823-6823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study evaluates whether combining

methodsWe analyzed data from 93 high-risk PCa patients who underwent

resultsThe five key input variables were as follows: binarized CAPRA score, maximal intraprostatic PSMA uptake intensity (SUVmax), presence of bone metastases, nodal involvement at common iliac bifurcation, and seminal vesicle infiltration. The PGM achieved superior predictive performance with a balanced accuracy of 0.73, sensitivity of 0.60, and specificity of 0.86, substantially outperforming both the LR (balanced accuracy: 0.50, sensitivity: 0.00, specificity: 1.00) and CAPRA (balanced accuracy: 0.59, sensitivity: 0.20, specificity: 0.99). The decision tree provided an explainable classifier with CAPRA as a primary branch node, followed by SUVmax and specific PET-detected tumor sites.

conclusionsIntegrating

Indexed as

68Ga-PSMA-11 PET/CTCAPRA scoreearly biochemical recurrenceoutcome predictionprostate cancerSUVmax

Identifiers

PMID40723170
PMCPMC12293663

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.