Evidence map›Paper›PMID 40723192›Full record

ArticleCancers2025

An Integrated Clinical, Germline, Somatic, and In Silico Approach to Assess a Novel PMS2 Gene Variant Identified in Two Unrelated Lynch Syndrome Families.

Candida Fasano, Antonia Lucia Buonadonna, Giovanna Forte, Martina Lepore Signorile, Valentina Grossi, Katia De Marco, Paola Sanese, Andrea Manghisi, Nicoletta Maria Tutino, Raffaele Armentano and 3 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Candida FasanoMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Antonia Lucia BuonadonnaMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Giovanna ForteMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Martina Lepore SignorileMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Valentina GrossiMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.ORCID 0000-0003-3843-1618
Katia De MarcoMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Paola SaneseMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Andrea ManghisiMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Nicoletta Maria TutinoMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Raffaele ArmentanoHistopathology Unit, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.ORCID 0000-0003-1661-5504
Anna Maria ValentiniHistopathology Unit, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.ORCID 0000-0002-6798-808X
Vittoria DisciglioMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
Cristiano SimoneMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.

Funding

Carlo Erba Foundation Award Cecilia Cioffrese for young researcher to M.L.S.European Union - Next Generation EU - NRRP M6C2 Investment 2.1 Enhancement and strengthening of biomedical research in the NHS (PNRR-POC-2023-12378288) to V.GItalian Ministry of Health Ricerca Corrente 2023-2025 to V.G.Italian Ministry of Health Ricerca Corrente 2024-2026 to C.F. and V.DItalian Ministry of Health Ricerca Corrente 2024-2026 to C.S.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA mismatch repairgastrointestinal cancerLynch syndromemismatch repair endonuclease PMS2variant of uncertain significance

Identifiers

PMID40723192
PMCPMC12293971

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.