Evidence map›Paper›PMID 40723801›Full record

ArticleBiomolecules2025

Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Injection of the Growth Factors-Rich Catfish Skin-Derived Fraction-B: An Introductory Report.

Jassim M Al-Hassan, Waleed M Renno, Sosamma Oommen, Divya Nair, Bincy Maniyalil Paul, Bincy Mathew, Jijin Kumar, Afna Ummerkutty, Cecil Pace-Asciak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jassim M Al-HassanHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, Kuwait.ORCID 0000-0002-4950-028X
Waleed M RennoDepartment of Anatomy, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait City, Kuwait.ORCID 0000-0001-9024-9712
Sosamma OommenHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, Kuwait.ORCID 0000-0002-3365-2553
Divya NairBiological Sciences Department, Faculty of Science, Shedadiya Campus, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.
Bincy Maniyalil PaulBiological Sciences Department, Faculty of Science, Shedadiya Campus, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.ORCID 0009-0008-8882-7454
Bincy MathewHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, Kuwait.
Jijin KumarDepartment of Anatomy, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait City, Kuwait.
Afna UmmerkuttyHealth Sciences Research Centre, Khaldiya Campus, Abdullah Al-Salem University, P.O. Box 2249, Safat 13023, Kuwait City, Kuwait.
Cecil Pace-AsciakTranslational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON M5G OA4, Canada.ORCID 0009-0003-1392-4923

Funding

KFAS KFAS 2013120701C; KFAS CN20-13MM-01
6 · The paper itself

Abstract

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. This study investigated the regenerative potential of Fraction-B (FB), a catfish skin-derived preparation rich in growth factors, in a T1D rat model to regenerate active β-cells. Sprague Dawley rats with T1D caused by streptozotocin injection received daily intraperitoneal injections of FB for 8 weeks. FB treatment significantly reduced blood glucose to a level close to that of normal control animals, increased serum insulin and C-peptide, and restored pancreatic insulin content. Histopathological and immunohistochemical analyses confirmed the regeneration of insulin-producing β-cells in pancreatic islets. FB treatment also improved diabetes-related health issues through a reduction in inflammation and oxidative stress, and an improvement in lipid profiles without toxicity or side effects. The regenerated β-cells remained functional for 48 weeks without the use of immunosuppressants, until the animals were sacrificed. These findings suggest FB treatment to be a promising procedure for translational research into T1D treatment.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Insulin-Secreting CellsIntercellular Signaling Peptides and ProteinsRegenerationSkinAnimalsBlood GlucoseCatfishesDisease Models, AnimalInflammationInjections, IntraperitonealInsulinMaleOxidative StressRatsBlood GlucoseInsulinIntercellular Signaling Peptides and ProteinscatfishdiabetesFraction-Bgrowth factorslipidsproteinsregenerationstem cellsβ-cells

Identifiers

PMID40723801
PMCPMC12292217

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.