Evidence mapPaperPMID 40723974Full record

ArticleAntibiotics (Basel, Switzerland)2025

Synthetic Human Lactoferrin Peptide hLF(1-11) Shows Antifungal Activity and Synergism with Fluconazole and Anidulafungin Towards

Carlo Brouwer, Youp van der Linden, Maria Rios Carrasco, Saleh Alwasel, Tarad Abalkhail, Fatimah O Al-Otibi, Teun Boekhout, Mick M Welling

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlo BrouwerCBMR Scientific Inc., Edmonton, AB T6J4V9, Canada.ORCID 0000-0002-6093-7116
Youp van der LindenWesterdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Maria Rios CarrascoWesterdijk Fungal Biodiversity Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Saleh AlwaselCollege of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Tarad AbalkhailCollege of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Fatimah O Al-OtibiCollege of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-3629-5755
Teun BoekhoutCollege of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Mick M WellingDepartment of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-2249-5601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction

methodsSusceptibility of the yeasts to hLF(1-11) was tested with a microdilution method to determine minimum inhibitory concentrations (MICs). A total of 59 strains belonging to 16 species of

resultsMean MIC values of all susceptible strains ranged from 16.66 ± 6.46 μg/mL to 45.83 ± 10.21 μg/mL. There were no statistical differences in the susceptibility of hLF(1-11) for

conclusionshLF(1-11) inhibits the growth of yeasts that belong to the genus

Indexed as

Candida/Candidozyma aurisclinical isolatesdrug resistanthLF(1-11)lactoferrin peptidesynergy

Identifiers

PMID40723974
PMCPMC12291840

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.