Evidence map›Paper›PMID 40724062›Full record

ArticleInternational journal of environmental research and public health2025

Nationwide Spatial Patterns and Maternal and Birth-Related Factors Associated with Orofacial Clefts in Brazil.

Luis Gustavo Souza Santos, Vandilson Rodrigues, Jessilene Ribeiro Rocha, Mila Roselaine Lima de Assunção, Marcio Vinícius Campos Borges, Maria Carmen Fontoura Nogueira da Cruz

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luis Gustavo Souza SantosDentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.
Vandilson RodriguesDentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.ORCID 0000-0002-6785-7864
Jessilene Ribeiro RochaDentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.
Mila Roselaine Lima de AssunçãoDentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.ORCID 0000-0003-3943-6496
Marcio Vinícius Campos BorgesDentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.ORCID 0000-0002-6401-1513
Maria Carmen Fontoura Nogueira da CruzDentistry Graduate Program, Federal University of Maranhão, São Luís 65085-580, Brazil.

Funding

capes finance code 001
6 · The paper itself

Abstract

This study aimed to identify spatial clustering and maternal and birth-related factors associated with the incidence of orofacial clefts in Brazil from 2001 to 2022. A nationwide ecological study was conducted in Brazil using data from 2001 to 2022 obtained from the Brazilian Live Birth Information System (SINASC). The municipality was used as the spatial unit of analysis. Variables included maternal age and education, newborn sex, gestational age, birth weight, and skin color/ethnicity. Univariate and bivariate global and local Moran's I indices were used to assess spatial autocorrelation. A total of 234 municipalities (4.2%) formed high-high spatial clusters, primarily in the South and Southeast, while 431 municipalities (7.7%) formed low-low clusters, mostly in the Northeast (Moran's I = 0.121, 95% CI: 0.107 to 0.135). High-high clusters had a lower median proportion of adolescent mothers (≤19 years: 17.4%) and a higher proportion of mothers aged ≥ 35 years (12.9%) compared to low-low clusters (23.5% and 8.7%, respectively;

Indexed as

Cleft LipCleft PalateAdolescentAdultBirth WeightBrazilFemaleHumansIncidenceInfant, NewbornMaleMaternal AgePregnancyRisk FactorsSpatial AnalysisYoung AdultBrazilepidemiologyorofacial cleftsspatial analysis

Identifiers

PMID40724062
PMCPMC12295512

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.