Evidence map›Paper›PMID 40724516›Full record

ReviewLife (Basel, Switzerland)2025

The Impact of Salvage Radiotherapy in Recurrent Endometrial Cancer: A Review Focusing on Early-Stage, Endometrial Cancer Locoregional Relapses.

Emmanouil Maragkoudakis, Theodoros Panoskaltsis, Kitty Pavlakis, Maria Grenzelia, Evangelia Kavoura, Georgios Papageorgiou, Ioannis Georgakopoulos, Andromachi Kougioumtzopoulou, Efrosyni Kypraiou, Nikolaos Trogkanis and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emmanouil MaragkoudakisDepartment of Clinical Radiation Oncology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0003-2647-3677
Theodoros PanoskaltsisSecond Department of Obstetrics and Gynecology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Kitty PavlakisK Pathology Department, IASO Women's Hospital, 15123 Athens, Greece.
Maria GrenzeliaRadiation Oncology Centre, Iaso General Clinic, 15123 Athens, Greece.
Evangelia KavouraK Pathology Department, IASO Women's Hospital, 15123 Athens, Greece.ORCID 0000-0003-1278-7499
Georgios PapageorgiouSecond Medical Oncology Department, Iaso General Clinic, 15123 Athens, Greece.ORCID 0000-0002-8370-9802
Ioannis GeorgakopoulosRadiation Oncology Unit, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-6354-9805
Andromachi KougioumtzopoulouDepartment of Clinical Radiation Oncology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Efrosyni KypraiouDepartment of Clinical Radiation Oncology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Nikolaos TrogkanisDepartment of Clinical Radiation Oncology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Evangelos MaragkoudakisRadiation Oncology Centre, Iaso General Clinic, 15123 Athens, Greece.
Vassilis KoulouliasDepartment of Clinical Radiation Oncology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0003-2082-7323
Anna ZygogianniRadiation Oncology Unit, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesDefinitive radiotherapy (RT) is a frequently employed salvage option in early-stage, endometrial cancer (EC) loco-regional recurrence patients. Local control (LC) and survival rates are highly variable in the literature. The aim of this review is to assess the impact of modern salvage radiotherapy (SRT) in this group of patients.

methodsA systematic review of the literature was performed, focusing on studies that included EC local recurrence patients receiving SRT after 2000 to reflect advances in radiotherapy techniques. Our report followed the principles as outlined in the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Nine studies were included in our analysis with a total sample size of 648 patients.

conclusionsSRT offers excellent LC rates in this group of patients with minimal ≥ grade 3 toxicity. Salvage rates are limited by the presence of well-known risk factors for loco-regional relapses, with distant control being the primary mode of failure, resulting in lower survival rates. The decision to omit adjuvant RT should be weighed against the anticipated salvage outcomes in case of relapse.

Indexed as

endometrial cancer recurrencenovel treatment strategiessalvage brachytherapysalvage radiotherapyuterine cancervaginal relapse

Identifiers

PMID40724516
PMCPMC12297922

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.