Evidence map›Paper›PMID 40724804›Full record

ArticleInternational journal of molecular sciences2025

Administration of Adipose-Derived Stem Cells Lowers the Initial Levels of IL6 and TNF-Alpha in the Rat Model of Necrotizing Enterocolitis.

Marek Wolski, Tomasz Ciesielski, Kasper Buczma, Łukasz Fus, Agnieszka Girstun, Joanna Trzcińska-Danielewicz, Agnieszka Cudnoch-Jędrzejewska

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marek WolskiDepartment of Pediatric Surgery, Medical University of Warsaw, Zwirki i Wigury 63a, 02-091 Warsaw, Poland.ORCID 0000-0003-0550-1915
Tomasz CiesielskiLaboratory of Centre for Preclinical Research, 1st Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.ORCID 0000-0003-1929-7767
Kasper BuczmaLaboratory of Centre for Preclinical Research, 1st Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.
Łukasz FusDepartment of Pathology, Medical University of Warsaw, Pawinskiego 7, 02-106 Warsaw, Poland.
Agnieszka GirstunDepartment of Molecular Biology, Institute of Biochemistry, Faculty of Biology, University of Warsaw, Ilji Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0001-6618-1383
Joanna Trzcińska-DanielewiczDepartment of Molecular Biology, Institute of Biochemistry, Faculty of Biology, University of Warsaw, Ilji Miecznikowa 1, 02-096 Warsaw, Poland.ORCID 0000-0001-5504-1553
Agnieszka Cudnoch-JędrzejewskaLaboratory of Centre for Preclinical Research, 1st Chair and Department of Experimental and Clinical Physiology, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.

Funding

National Science Center 2019/35/N/NZ5/02420
6 · The paper itself

Abstract

Research in the field of stem cells in necrotizing enterocolitis has primarily focused on the curative role of specific cells-mostly bone marrow and amniotic fluid stem cells. The impact of stem cells on reducing inflammatory cytokine levels in the necrotizing enterocolitis (NEC) model has been studied in accordance with the effects they pose on histopathology. Taking into consideration the possible paracrine mechanism of action of stem cells, our group hypothesized that lowering the initial levels of proinflammatory cytokines may be one of the mechanisms affecting the clinical outcome. A self-modified rat NEC model was used to show the effect of intraperitoneal administration of adipose derived stem cells on the initial levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alfa) in comparison with the interleukin levels in NEC animals and control animals without adipose-derived stem cells (ADSCs) injection. We showed a statistically significant difference in the levels of interleukins when comparing an ADSC injected group and an NEC group. This suggests that one of the mechanisms in which stem cells impact the clinical outcomes in NEC may be by alleviating the initial levels of proinflammatory cytokines.

Indexed as

Adipose TissueEnterocolitis, NecrotizingInterleukin-6Stem CellsStem Cell TransplantationTumor Necrosis Factor-alphaAnimalsDisease Models, AnimalFemaleMaleRatsIl6 protein, ratInterleukin-6Tumor Necrosis Factor-alphaadipose-derived stem cellsinflammation mediatorsnecrotizing enterocolitis

Identifiers

PMID40724804
PMCPMC12294573

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.