Evidence map›Paper›PMID 40724862›Full record

ArticleInternational journal of molecular sciences2025

Polymorphisms in Base Excision Repair Genes and Association with Multiple Sclerosis in a Pilot Study on a Central European Population.

Beata Filipek, Anna Macieja, Aleksandra Binda, Elzbieta Miller, Mariola Swiderek-Matysiak, Mariusz Stasiolek, Maksymilian Stela, Ireneusz Majsterek, Tomasz Poplawski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Beata FilipekDepartment of Microbiology and Pharmaceutical Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.ORCID 0000-0003-4166-5650
Anna MaciejaDepartment of Microbiology and Pharmaceutical Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.ORCID 0000-0001-6056-7808
Aleksandra BindaDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.ORCID 0009-0007-6173-4525
Elzbieta MillerDepartment of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland.ORCID 0000-0002-7029-1857
Mariola Swiderek-MatysiakDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland.ORCID 0000-0002-6779-308X
Mariusz StasiolekDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland.ORCID 0000-0002-2582-1708
Maksymilian StelaBiohazard Prevention Centre, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Ireneusz MajsterekDepartment of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Lodz, Poland.
Tomasz PoplawskiDepartment of Microbiology and Pharmaceutical Biochemistry, Medical University of Lodz, Mazowiecka 5, 92-215 Lodz, Poland.ORCID 0000-0003-2300-7339

Funding

NCN 2019/35/O/NZ5/02270
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and neurodegeneration. While its etiology remains unclear, both genetic and environmental factors, including oxidative stress, have been implicated in the development of the disease. The base excision repair (BER) pathway plays a critical role in repairing oxidative DNA damage. This study investigated the association between polymorphisms in BER-related genes and MS susceptibility in a Central European population. Ten SNPs across seven BER genes were genotyped in 102 patients with MS and 118 healthy controls. Six SNPs were significantly associated with MS. Increased risk was observed for rs25478 in XRCC1 (OR = 2.37, 95% CI: 1.44-3.91,

Indexed as

DNA RepairGenetic Predisposition to DiseaseMultiple SclerosisPolymorphism, Single NucleotideAdultCase-Control StudiesDNA GlycosylasesEndodeoxyribonucleasesExcision RepairFemaleGenetic Association StudiesGenotypeHaplotypesHumansMaleMiddle AgedDNA GlycosylasesEndodeoxyribonucleasesMBD4 protein, humanmutY adenine glycosylaseX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanbase excision repairgene polymorphismsmultiple sclerosis

Identifiers

PMID40724862
PMCPMC12295973

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.