Evidence map›Paper›PMID 40724955›Full record

ArticleInternational journal of molecular sciences2025

Identification and Characterization of a Translational Mouse Model for Blood-Brain Barrier Leakage in Cerebral Small Vessel Disease.

Ruxue Jia, Gemma Solé-Guardia, Vivienne Verweij, Jessica M Snabel, Bram Geenen, Anil Man Tuladhar, Robert Kleemann, Amanda J Kiliaan, Maximilian Wiesmann

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruxue JiaDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition & Behavior, Center for Medical Neuroscience, Preclinical Imaging Center PRIME, Radboud Alzheimer Center, Radboudumc, 6525 EZ Nijmegen, The Netherlands.
Gemma Solé-GuardiaDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition & Behavior, Center for Medical Neuroscience, Preclinical Imaging Center PRIME, Radboud Alzheimer Center, Radboudumc, 6525 EZ Nijmegen, The Netherlands.ORCID 0000-0003-1154-8904
Vivienne VerweijDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition & Behavior, Center for Medical Neuroscience, Preclinical Imaging Center PRIME, Radboud Alzheimer Center, Radboudumc, 6525 EZ Nijmegen, The Netherlands.
Jessica M SnabelDepartment of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands.
Bram GeenenDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition & Behavior, Center for Medical Neuroscience, Preclinical Imaging Center PRIME, Radboud Alzheimer Center, Radboudumc, 6525 EZ Nijmegen, The Netherlands.ORCID 0000-0001-7838-3097
Anil Man TuladharDepartment of Neurology, Research Institute for Medical Innovation, Donders Institute for Brain, Cognition and Behavior, Radboudumc, 6525 GA Nijmegen, The Netherlands.
Robert KleemannDepartment of Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), 2333 CK Leiden, The Netherlands.ORCID 0000-0002-1350-0149
Amanda J KiliaanDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition & Behavior, Center for Medical Neuroscience, Preclinical Imaging Center PRIME, Radboud Alzheimer Center, Radboudumc, 6525 EZ Nijmegen, The Netherlands.ORCID 0000-0002-2158-6210
Maximilian WiesmannDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Donders Institute for Brain, Cognition & Behavior, Center for Medical Neuroscience, Preclinical Imaging Center PRIME, Radboud Alzheimer Center, Radboudumc, 6525 EZ Nijmegen, The Netherlands.ORCID 0000-0002-1412-398X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood-brain barrier (BBB) dysfunction is a hallmark of cerebral small vessel disease (cSVD). This study aimed to identify a mouse model that replicates BBB impairment and shares key cSVD risk factors. Transgenic db/db and LDLr

Indexed as

Blood-Brain BarrierCerebral Small Vessel DiseasesAnimalsDiet, High-FatDisease Models, AnimalMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, TransgenicReceptors, LDLReceptors, LDLblood–brain barrier dysfunctioncerebral small vessel disease (cSVD)dynamic contrast-enhanced MRI (DCE-MRI)endothelial dysfunctionneuroinflammation

Identifiers

PMID40724955
PMCPMC12294681

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.