Evidence map›Paper›PMID 40724959›Full record

SynthesisInternational journal of molecular sciences2025

Multiomics Integration of Parkinson's Disease Datasets Reveals Unexpected Roles of IRE1 in Its Pathology.

Bianka Alexandra Pasat, Matthieu Moncan, Eleftherios Pilalis, Afshin Samali, Aristotelis Chatziioannou, Adrienne M Gorman

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bianka Alexandra PasatApoptosis Research Centre, University of Galway, H91W2TY Galway, Ireland.ORCID 0009-0002-9511-4184
Matthieu MoncanApoptosis Research Centre, University of Galway, H91W2TY Galway, Ireland.ORCID 0000-0002-8813-8754
Eleftherios PilalisCenter of Systems Biology, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str, 11527 Athens, Greece.ORCID 0000-0002-5253-5256
Afshin SamaliApoptosis Research Centre, University of Galway, H91W2TY Galway, Ireland.ORCID 0000-0002-8610-8375
Aristotelis ChatziioannouCenter of Systems Biology, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str, 11527 Athens, Greece.ORCID 0000-0003-2078-0844
Adrienne M GormanApoptosis Research Centre, University of Galway, H91W2TY Galway, Ireland.ORCID 0000-0002-6068-0058

Funding

Cell Stress Discoveries Limited and from the European Union's Horizon 2020 under the Marie Skłodowska-Curie grant 945425 ('DevelopMed')Next-generation anti-sense molecules for Parkinson's disease therapy, TheraSyn GSRT 2E∆K - 01291Precision Oncology Ireland 13/RC/2073Research Ireland 18/CRT/6214Research Ireland 18/SPP/3522Research Ireland Strategic Partnership Programme 18/SPP/3522
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease. It primarily affects the motor system but is also associated with a range of cognitive impairments that can manifest early in disease progression, indicating its multifaceted nature. In this paper, we performed a meta-analysis of transcriptomics and proteomics data using MultiOmicsIntegrator to gain insights into the post-transcriptional modifications and deregulated pathways associated with this disease. Our results reveal differential isoform usage between control and PD patient brain samples that result in enriched alternative splicing events, including an extended UTR length, domain loss, and the upregulation of non-coding isoforms. We found that Inositol-Requiring Enzyme 1 (IRE1) is active in PD samples and examined the role of its downstream signaling through X-box binding mRNA 1 (

Indexed as

EndoribonucleasesParkinson DiseaseProtein Serine-Threonine KinasesAlternative SplicingGene Expression ProfilingHumansMultiomicsProteomicsRNA, MessengerSignal TransductionTranscriptomeX-Box Binding Protein 1EndoribonucleasesERN1 protein, humanProtein Serine-Threonine KinasesRNA, MessengerX-Box Binding Protein 1XBP1 protein, humanInositol-Requiring Enzyme 1 (IRE1)isoform usagemultiomicsParkinson’s disease (PD)regulated IRE1-dependent decay (RIDD)

Identifiers

PMID40724959
PMCPMC12295087

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.