Evidence map›Paper›PMID 40725035›Full record

ArticleInternational journal of molecular sciences2025

Impact of SOD1 Transcript Variants on Amyotrophic Lateral Sclerosis Severity.

Matteo Bordoni, Eveljn Scarian, Camilla Viola, Francesca Dragoni, Rosalinda Di Gerlando, Bartolo Rizzo, Luca Diamanti, Stella Gagliardi, Orietta Pansarasa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matteo BordoniCellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0000-0001-9461-756X
Eveljn ScarianCellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0000-0002-6703-1755
Camilla ViolaCellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0009-0005-1410-5510
Francesca DragoniMolecular Biology and Transcriptomics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0000-0001-7608-3306
Rosalinda Di GerlandoMolecular Biology and Transcriptomics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0000-0002-7834-0342
Bartolo RizzoGolgi Cenci Foundation, Corso S. Martino 10, 20081 Abbiategrasso, Italy.ORCID 0009-0001-5799-7732
Luca DiamantiNeuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
Stella GagliardiMolecular Biology and Transcriptomics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0000-0002-6589-6907
Orietta PansarasaCellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.ORCID 0000-0002-3041-0612

Funding

Italian Ministry of Health Ricerca Corrente 2022-2024
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that affects motor neurons of people, leading to death. This pathology can be caused by mutations in different genes, including superoxide dismutase 1 (

Indexed as

Amyotrophic Lateral SclerosisSuperoxide Dismutase-1AdultAgedCell Line, TumorDisease ProgressionFemaleHumansLeukocytes, MononuclearMaleMiddle AgedRNA, MessengerSeverity of Illness IndexRNA, MessengerSOD1 protein, humanSuperoxide Dismutase-1amyotrophic lateral sclerosisdisease severityoxidative stressSOD1transcript

Identifiers

PMID40725035
PMCPMC12295590

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.