Evidence mapPaperPMID 40725092Full record

ArticleInternational journal of molecular sciences2025

[1,3]Thiazolo[3,2-b][1,2,4]triazolium Salts as Effective Antimicrobial Agents: Synthesis, Biological Activity Evaluation, and Molecular Docking Studies.

Mykhailo Slivka, Boris Sharga, Daryna Pylypiv, Hanna Aleksyk, Nataliya Korol, Maksym Fizer, Olena I Fedurcya, Oleksandr G Pshenychnyi, Ruslan Mariychuk

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mykhailo SlivkaEducational Scientific Institute of Chemistry and Ecology, Uzhhorod National University, Fedyntsa Str. 53/1, 88000 Uzhhorod, Ukraine.
Boris ShargaFaculty of Biology, Uzhhorod National University, Voloshyna Str. 32, 88000 Uzhhorod, Ukraine.ORCID 0000-0002-3934-7525
Daryna PylypivFaculty of Medicine, Uzhhorod National University, Narodna Sq. 1, 88000 Uzhhorod, Ukraine.
Hanna AleksykEducational Scientific Institute of Chemistry and Ecology, Uzhhorod National University, Fedyntsa Str. 53/1, 88000 Uzhhorod, Ukraine.ORCID 0000-0002-1659-1699
Nataliya KorolEducational Scientific Institute of Chemistry and Ecology, Uzhhorod National University, Fedyntsa Str. 53/1, 88000 Uzhhorod, Ukraine.ORCID 0000-0001-7155-1676
Maksym FizerDepartment of Chemistry, University of Nevada, Reno, 1664 N. Virginia Street, Reno, NV 89557-0216, USA.ORCID 0000-0001-6583-3159
Olena I FedurcyaTranscarpathian Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine, Sobranetska Str. 96, 88000 Uzhhorod, Ukraine.ORCID 0009-0005-3579-5290
Oleksandr G PshenychnyiTranscarpathian Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine, Sobranetska Str. 96, 88000 Uzhhorod, Ukraine.ORCID 0009-0004-4908-0360
Ruslan MariychukDepartment of Ecology, Faculty of Humanity and Natural Sciences, University of Presov in Presov, 17th November Str. 1, 08001 Presov, Slovakia.ORCID 0000-0001-8464-4142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study focuses on the search for new effective synthetic antimicrobial compounds as a tool against the widespread presence of microorganisms resistant to existing drugs. Five derivatives of [1,3]thiazolo[3,2-b][1,2,4]triazoles were synthesized using an accessible protocol based on electrophilic heterocyclization and were characterized using infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies, and their in vitro antimicrobial and antifungal activities were evaluated using the agar plate diffusion method and the microdilution plate procedure. Both antibacterial (Gram-positive and Gram-negative) and antifungal activities were found for the examined samples. The minimum inhibitory concentration (MIC) varied from 0.97 to 250 µg/mL, and the minimum bactericidal concentration (MBC) from 1.95 to 500 µg/mL. Compound

Indexed as

Antifungal AgentsAnti-Infective AgentsTriazolesAnti-Bacterial AgentsCandida albicansMicrobial Sensitivity TestsMolecular Docking SimulationSaccharomyces cerevisiaeStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsTriazolesantibacterial and antifungal actionDFTelectrophilic heterocyclizationmolecular dockingthiazoletriazole

Identifiers

PMID40725092
PMCPMC12294876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.