Evidence map›Paper›PMID 40725161›Full record

ArticleInternational journal of molecular sciences2025

Upregulation of the Antioxidant Response-Related microRNAs miR-146a-5p and miR-21-5p in Gestational Diabetes: An Analysis of Matched Samples of Extracellular Vesicles and PBMCs.

Jovana Stevanović, Ninoslav Mitić, Ana Penezić, Ognjen Radojičić, Daniela Ardalić, Milica Mandić, Vesna Mandić-Marković, Željko Miković, Miloš Brkušanin, Olgica Nedić and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jovana StevanovićInstitute for the Application of Nuclear Energy, University of Belgrade, 11080 Belgrade, Serbia.
Ninoslav MitićInstitute for the Application of Nuclear Energy, University of Belgrade, 11080 Belgrade, Serbia.ORCID 0000-0003-2756-6517
Ana PenezićInstitute for the Application of Nuclear Energy, University of Belgrade, 11080 Belgrade, Serbia.ORCID 0000-0002-2539-4507
Ognjen RadojičićClinic for Gynecology and Obstetrics "Narodni Front", 11000 Belgrade, Serbia.ORCID 0000-0001-6915-8509
Daniela ArdalićClinic for Gynecology and Obstetrics "Narodni Front", 11000 Belgrade, Serbia.
Milica MandićClinic for Gynecology and Obstetrics "Narodni Front", 11000 Belgrade, Serbia.
Vesna Mandić-MarkovićClinic for Gynecology and Obstetrics "Narodni Front", 11000 Belgrade, Serbia.ORCID 0000-0002-0005-8443
Željko MikovićClinic for Gynecology and Obstetrics "Narodni Front", 11000 Belgrade, Serbia.ORCID 0000-0002-4247-3290
Miloš BrkušaninCentre for Human Molecular Genetics, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-4316-9231
Olgica NedićInstitute for the Application of Nuclear Energy, University of Belgrade, 11080 Belgrade, Serbia.ORCID 0000-0003-2042-0056
Zorana DobrijevićInstitute for the Application of Nuclear Energy, University of Belgrade, 11080 Belgrade, Serbia.ORCID 0000-0002-4652-7719

Funding

Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-136/2025-03/200019
6 · The paper itself

Abstract

MicroRNA-based regulatory mechanisms show disturbances related to oxidative stress (OS) interconnected with inflammation (IFM), as well as impairments associated with gestational diabetes (GDM). The aim of this study was to assess the diagnostic and prognostic significance of the OS/IFM-related microRNA in GDM by using peripheral blood mononuclear cells (PBMCs) and serum-derived extracellular vesicles (EVs) as biological samples. We selected the known OS/IFM-associated microRNAs miR-146a-5p, miR-155-5p, and miR-21-5p as candidates for our GDM biomarker analysis. Quantitative RT-PCR was employed for relative quantification of the selected microRNAs from paired samples of PBMCs and EVs derived from patients with GDM and healthy controls (

Indexed as

AntioxidantsDiabetes, GestationalExtracellular VesiclesLeukocytes, MononuclearMicroRNAsAdultBiomarkersCase-Control StudiesFemaleHumansOxidative StressPregnancyUp-RegulationAntioxidantsBiomarkersMicroRNAsMIRN146 microRNA, humanMIRN21 microRNA, humanadverse outcomesgestational diabetesironmiR-146a-5pmiR-155-5pmiR-21-5poxidative stressredox statussuperoxide dismutase

Identifiers

PMID40725161
PMCPMC12295923

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.