Evidence map›Paper›PMID 40725415›Full record

ArticleGenes2025

Methylation of LINE-1 Retroelement in People with Type 1 Diabetes.

Andromachi Katsanou, Charilaos Kostoulas, Evangelos Liberopoulos, Agathocles Tsatsoulis, Ioannis Georgiou, Stelios Tigas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andromachi KatsanouDepartment of Endocrinology, University of Ioannina, 45110 Ioannina, Greece.
Charilaos KostoulasLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-0769-0257
Evangelos LiberopoulosFirst Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.
Agathocles TsatsoulisDepartment of Endocrinology, University of Ioannina, 45110 Ioannina, Greece.
Ioannis GeorgiouLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-0308-5703
Stelios TigasDepartment of Endocrinology, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0001-7325-8983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEmerging research indicates that alterations in the methylation of retrotransposons may contribute to genomic instability and cellular aging in various autoimmune disorders and diabetes mellitus (DM). As relevant information for people with type 1 diabetes mellitus (PwT1D) is limited, we aimed to investigate long interspersed nuclear element-1 (LINE-1) methylation status in this population.

methodsDNA methylation levels and patterns of LINE-1 were examined in the peripheral blood of 35 PwT1D and 28 healthy controls (age- and sex-matched), by using the COmbined Bisulfite Restriction Analysis methodology (COBRA).

resultsTotal LINE-1 methylation rate (mC) was higher in PwT1D compared to controls [47.3% (46.6-47.8%) vs. 46.5% (44.7-47.3%),

conclusionsPwT1D were found to have higher total LINE-1 methylation rate (mC) compared to healthy controls. The partial methylation pattern (uCmC) was less frequently observed in these patients and was negatively associated with the glycemic status and the age at diagnosis of T1D, while demonstrating a positive correlation with disease duration.

Indexed as

Diabetes Mellitus, Type 1DNA MethylationLong Interspersed Nucleotide ElementsRetroelementsAdolescentAdultCase-Control StudiesFemaleHumansMaleMiddle AgedYoung AdultRetroelementsDNA methylationLINE-1 retroelementtype 1 diabetes

Identifiers

PMID40725415
PMCPMC12294285

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.