Evidence map›Paper›PMID 40725464›Full record

ArticleGenes2025

The Distribution and Survival Association of Genetic Polymorphisms in Thai Patients with Hepatocellular Carcinoma According to Underlying Liver Disease.

Theint Cho Zin Aung, Bootsakorn Boonkaew, Maneerat Chayanupatkul, Kittiyod Poovorawan, Natthaya Chuaypen, Pisit Tangkijvanich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Theint Cho Zin AungDivision of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0009-0002-2158-5610
Bootsakorn BoonkaewCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-9548-1059
Maneerat ChayanupatkulDivision of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-1649-5373
Kittiyod PoovorawanDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 14000, Thailand.ORCID 0000-0001-7016-7605
Natthaya ChuaypenMetabolic Disease in Gastrointestinal and Urinary System Research Unit, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-5415-510X
Pisit TangkijvanichCenter of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-2926-8671

Funding

The NSRF via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation (PMU-B) B36G660010
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe influence of single-nucleotide polymorphisms (SNPs) on hepatocellular carcinoma (HCC) in terms of etiological factors remains to be explored. This study evaluated the distribution of

methodsThis study included 564 patients with HCC: 254 with MASLD-HCC and 310 with VIRAL-HCC. The SNPs were determined by real-time PCR using TaqMan assays.

resultsThe mean ages of patients with MASLD-HCC and VIRAL-HCC were 68.4 vs. 60.9 years (

conclusionsOur data demonstrated that the prevalence of the SNPs significantly differed between MASLD-HCC and VIRAL-HCC. The

Indexed as

Carcinoma, HepatocellularLipaseLiver NeoplasmsMembrane ProteinsPolymorphism, Single Nucleotide17-Hydroxysteroid DehydrogenasesAcyltransferasesAgedFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedPhospholipases A2, Calcium-IndependentSoutheast Asian People17-Hydroxysteroid DehydrogenasesAcyltransferasesHSD17B13 protein, humanLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanTM6SF2 protein, humanhepatocellular carcinomaHSD17B13PNPLA3polymorphismssteatotic liver diseaseTM6SF2

Identifiers

PMID40725464
PMCPMC12295243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.