Evidence map›Paper›PMID 40725474›Full record

ArticleGenes2025

Brain and CSF Alzheimer's Biomarkers Are Associated with SERPINE1 Gene Expression.

Cynthia Picard, Henrik Zetterberg, Kaj Blennow, Sylvia Villeneuve, Judes Poirier, On Behalf Of The Prevent-Ad Research Group

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In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cynthia PicardDouglas Mental Health University Institute, Montréal, QC H4H 1R3, Canada.ORCID 0000-0003-1107-6839
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
Sylvia VilleneuveDouglas Mental Health University Institute, Montréal, QC H4H 1R3, Canada.
Judes PoirierDouglas Mental Health University Institute, Montréal, QC H4H 1R3, Canada.ORCID 0000-0002-8018-4545
On Behalf Of The Prevent-Ad Research GroupCentre for the Studies on Prevention of Alzheimer's Disease, Montréal, QC H4H 1R3, Canada.

Funding

CIHR CIHR #PJT 153287 & PJT 178210
6 · The paper itself

Abstract

backgroundSERPINE1, also known as plasminogen activator inhibitor (PAI), has been proposed as a potential blood biomarker for the early detection and diagnosis of Alzheimer's disease (AD). Expanding on previous studies, this research contrasted SERPINE1 levels in CSF and brain tissue of AD patients and those at risk for AD with established AD biomarkers.

methodsUtilizing OLINK and immunoassay methods, CSF SERPINE1 protein levels were quantified across two separate cohorts: PREVENT-AD and ADNI. Microarray and RNAseq were used to measure tissue

resultsAt the pre-clinical stage, elevated CSF levels of pTau, tTau and synaptic markers, alongside reduced hippocampal volume, correlate with CSF SERPINE1 levels. Elevated cortical

conclusionsCSF SERPINE1 levels can be used as an early biomarker for the detection of pathological changes associated with AD. Higher SERPINE1 levels correlate more strongly with tau pathology than with amyloid formation or deposition.

Indexed as

Alzheimer DiseaseBrainPlasminogen Activator Inhibitor 1AgedAged, 80 and overBiomarkersFemaleHumansMaleRNA, Messengertau ProteinsBiomarkersPlasminogen Activator Inhibitor 1RNA, MessengerSERPINE1 protein, humantau ProteinsAlzheimer’s diseasebiomarkersSERPINE1

Identifiers

PMID40725474
PMCPMC12294632

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.