Evidence map›Paper›PMID 40726139›Full record

ArticleCNS neuroscience & therapeutics2025

Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.

Xin Jin, Xueying Wang, Dingxin Zheng, Pubing Yuan, Jianyu Li, Ting Qiu, Huixiong Zhang, Yifan Chen, Jinfan Zhang, Feifei Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xin JinThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Xueying WangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.ORCID 0000-0002-3026-052X
Dingxin ZhengThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Pubing YuanThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Jianyu LiThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Ting QiuDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
Huixiong ZhangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Yifan ChenThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.
Jinfan ZhangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.ORCID 0009-0003-9641-3829
Feifei WuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Qing LiuDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi, P. R. China.
Alessandro GrecucciDepartment of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Rovereto, Italy.ORCID 0000-0001-6043-2196
Yuanchao ZhangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, Sichuan, P. R. China.ORCID 0000-0001-8191-4899
Junling WangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi, P. R. China.ORCID 0000-0001-5117-5204
Xiaoping YiDepartment of Radiology, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, P. R. China.ORCID 0000-0002-4220-1981
Lena PalaniyappanDouglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-1640-7182
B Blair BradenCollege of Health Solutions, Arizona State University, Phoenix, Arizona, USA.

Funding

Fonds de Recherche du Québec - Santé CB-C2022Fundamental Research Funds for the Central Universities of Central South University 2024ZZTS0954National Natural Science Foundation of China U22A20377Project Program of National Clinical Research Center for Geriatric Disorders 2022LNJJ09The Scientific Research Program of FuRong Laboratory 2024PT5109
6 · The paper itself

Abstract

aimsThis study aimed to characterize the topological changes in glucose metabolism covariance networks in amyotrophic lateral sclerosis (ALS).

methodsWe assessed the interregional coordination of

resultsCompared to HC, ALS patients showed reduced small-worldness (lower normalized clustering coefficient, higher normalized characteristic path length) and decreased global and local efficiency, suggesting impaired global integration and local segregation. These network metrics correlated with disease progression and motor function. Regionally, altered degree centrality affected motor and default mode networks, and related to GABAa and mGluR5 receptor expression. Transcriptomic associations further linked these changes to immune function, synaptic signaling, and protein regulation. Bidirectional shifts in connectivity strength were observed, with both increased connectivity and disease progression independently predicting reduced survival.

conclusionOur findings may provide valuable biomarkers for monitoring the progression of ALS and suggest potential mechanistic pathways for the development of innovative therapeutic strategies for this disorder.

Indexed as

Amyotrophic Lateral SclerosisBrainGlucoseNerve NetAdultAgedDisease ProgressionFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyFluorodeoxyglucose F18GlucoseALSexcitotoxityglutamategraph‐theoretic analysisTDP‐43

Identifiers

PMID40726139
PMCPMC12304423

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.