ArticleCNS neuroscience & therapeutics2025
Cortical Hemodynamic Abnormalities Associated With Fine Motor Deficits in Mild Cognitive Impairment.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Neuromuscular control mechanism during posture-cognition dual task in mild cognitive impairment: a concurrent fNIRS-sEMG-COP study.GeroScience · 2026Article
- Cognitive and fine motor performance in people above 65 years of age with and without HIV.Scientific reports · 2026Article
- Correlation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.Behavioral and brain functions : BBF · 2025Article
- Cortical Hemodynamic Abnormalities Associated With Fine Motor Deficits in Mild Cognitive Impairment.CNS neuroscience & therapeutics · 2025Article
- Exploring the neural mechanisms of electroacupuncture for cognitive impairment in depression using functional near-infrared spectroscopy: a randomized controlled trial.Frontiers in psychiatry · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundIndividuals with mild cognitive impairment (MCI) often exhibit progressive deficits in bimanual coordination and fine motor dexterity. However, the neural mechanisms underlying these motor impairments remain poorly understood.
aimThis cross-sectional study employed functional near-infrared spectroscopy (fNIRS) to examine cortical hemodynamic responses during fine motor tasks in MCI.
methodsThirty individuals with MCI and 40 age-, sex-, and education-matched healthy controls (HCs) performed the Nine-Hole Peg Test (NHPT) while fNIRS monitored oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) responses in the prefrontal cortex (PFC), sensorimotor cortex (SMC), and visual cortex (VC).
resultsCompared to HCs, individuals with MCI exhibited significantly impaired NHPT performance, accompanied by reduced HbO responses in the right PFC and SMC during task performance. Furthermore, stepwise discriminant analysis identified a combination of right SMC HbO levels and NHPT scores as a significant predictor for distinguishing MCI from HCs, achieving an area under the curve (AUC) of 80.8%.
conclusionsThese findings provide novel evidence linking aberrant cortical hypoactivation in the motor and executive control regions to fine motor impairments in individuals with MCI, suggesting disrupted motor-cognitive integration in early cognitive decline. The integration of fNIRS-derived hemodynamic responses with functional motor assessments offers a promising non-invasive approach for MCI detection and personalized rehabilitation.
trial registrationThis study was registered with the Chinese Clinical Trial Registry (Registration No. ChiCTR2400082429) on March 28, 2024.
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