ArticleCNS neuroscience & therapeutics2025
Mapping Divergent Subfield-Specific Hippocampal Degeneration in Mild Cognitive Impairment Continuum: Volumetric, Cognitive, and Genetic Predictors of Accelerated Hippocampal Biological Aging.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.Brain and behavior · 2025Pooled it
- The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.Aging cell · 2026Review
- Mapping Divergent Subfield-Specific Hippocampal Degeneration in Mild Cognitive Impairment Continuum: Volumetric, Cognitive, and Genetic Predictors of Accelerated Hippocampal Biological Aging.CNS neuroscience & therapeutics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveTo investigate hippocampal subfield atrophy and biological aging across the mild cognitive impairment (MCI) continuum, we used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
methodsA cohort of 49 participants, categorized as cognitively normal (CN, n = 16), early MCI (EMCI, n = 16), or late MCI (LMCI, n = 17), underwent comprehensive neuroimaging, neuropsychological, and genetic assessments. High-resolution 3D T1-weighted MRI scans were processed using the volBrain platform and hippocampal subfield segmentation (HIPS) pipeline to quantify hippocampal subfield volumes and estimate biological age. Statistical analyses, including ANCOVA and stepwise regression, were employed to evaluate group differences and identify predictors of hippocampal biological age.
resultsThe results revealed significant volumetric reductions in LMCI, particularly within the CA1, CA4/dentate gyrus (DG), and stratum radiatum/lacunosum/moleculare (SRLM) subfields, with pronounced lateralized effects. Clinical and demographic covariates attenuated group differences in biological age, but volumetric adjustments highlighted a significant distinction between EMCI and LMCI, with EMCI exhibiting a higher biological age. Cognitive performance, as measured by the Montreal Cognitive Assessment (MoCA), emerged as a consistent predictor of biological age, while APOE ε4 carrier status was significantly elevated in LMCI patients. Regression analyses identified divergent contributions of CA2/3 (positively associated) and CA4/DG (negatively associated) volumes to biological age, underscoring the subfield-specific pathophysiological mechanisms. Asymmetry indices, although variably expressed across groups, offered limited predictive utility, with CA2/3 and CA4/DG asymmetries modestly influencing biological age.
conclusionThese findings support the integration of subfield-specific hippocampal volumetry and cognitive assessments in early diagnostic frameworks while highlighting the need for longitudinal studies to elucidate causal pathways linking subfield atrophy, biological aging, and cognitive decline.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.