SynthesisFrontiers in neurology2025
Effectiveness of dual-site transcranial magnetic stimulation on motor function and activities of daily living in stroke patients: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of repetitive transcranial magnetic stimulation combined with traditional Chinese Tuina for stroke: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Effect of transcranial magnetic stimulation on the limb function of stroke patients: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Research progress on the mechanisms and clinical applications of neuromodulation techniques for intervening in interhemispheric imbalance after stroke.Frontiers in neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dual-site transcranial magnetic stimulation (TMS) has emerged as a promising neuromodulation technique in stroke rehabilitation. By targeting multiple brain regions, dual-site TMS may enhance neuroplasticity more effectively than single-site stimulation. However, its clinical efficacy remains uncertain. Objective: To systematically evaluate the effects of dual-site TMS in improving motor function and activities of daily living (ADL) in patients with stroke. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) following PRISMA guidelines. Seven electronic databases were searched from inception to February 19, 2024. Studies comparing dual-site TMS with single-site TMS, sham dual-site TMS, or routine rehabilitation in stroke patients were included. Outcomes included Fugl-Meyer Assessment (FMA), FMA-Upper Limb (FMA-UL), Action Research Arm Test (ARAT), Barthel Index (BI), Modified Barthel Index (MBI), Wolf Motor Function Test (WMFT), and others. Methodological quality was assessed using the PEDro scale. Meta-analyses were performed using a random-effects model. Results: Fourteen RCTs involving 724 participants were included. Dual-site TMS significantly improved upper limb motor function compared with single-site TMS (MD = 7.07, 95% CI: 1.46 to 12.68, Conclusion: Dual-site TMS combined with routine rehabilitation is more effective than single-site TMS or sham dual-site TMS in improving motor function and ADL among stroke patients. These findings support its clinical application as an adjunct to conventional therapy. Further high-quality trials are needed to optimize stimulation protocols and confirm long-term effects.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.