ArticleJournal of family medicine and primary care2025
Comparison of inflammatory markers and nerve conduction studies in prediabetes and type two diabetes mellitus: A possible role in neuropathy.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objective: Data on the role of anti- and proinflammatory markers in diabetes and prediabetes and their associations with diabetic neuropathy are limited. Therefore, the aim of this study was to determine and compare the associations of inflammatory markers and nerve function with blood glucose levels among diabetic patients and prediabetic patients. Methods: This was a cross-sectional study consisting of 80 participants (40 diabetic patients and 40 prediabetic patients). The assessment involved a detailed history and neurological examination, including neuropathy symptom scoring (NSS) and the neuropathy deficit score (NDS), to grade neuropathy if present. Baseline investigations were performed, and HbA1c values were assessed in all the subjects. Serum TNFα and IL-10 levels were measured via enzyme-linked immunosorbent assay (ELISA). Nerve function was evaluated through a nerve conduction study. The data were subjected to an independent sample Results: The results revealed a significant increase in the concentrations of IL-10 ( Conclusions: The inflammatory markers TNF-α and IL-10 were significantly elevated in patients with diabetes compared with those with prediabetes, and these markers might contribute to neuropathy in patients with diabetes. However, no associations were found between inflammatory markers and nerve function.
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