ArticleFrontiers in immunology2025
Exploration of differential expression and biological significance of amino acid metabolism genes in osteoarthritis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Integrating multi-omics and machine learning to explore the role of amino acid metabolism in intervertebral disk degeneration.Frontiers in neurology · 2026Article
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Authors and funding
9 authors.
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Abstract
Background: Osteoarthritis (OA) is a widespread disorder affecting joints, recognized for cartilage wear and inflammatory responses, which substantially affects patients' quality of life. This research aim to discover amino acid metabolism-related differentially expressed genes (AAMRDEGs) and clarify their functions in OA pathogenesis. Methods: Herein, we conducted an analysis of combined GEO datasets (GSE55457, GSE55235, and GSE12021), identifying 169 AAMRDEGs and indicating their importance in chondrocyte function and inflammation. Furthermore, significant correlations were observed between various immune cell types, underscoring the intricate function of the immune system in OA. Thereafter, we developed highly accurate diagnostic models using LASSO regression and SVM methodologies, achieving an area under the curve > 0.9. Protein-protein interaction analysis revealed significant interactions among MTHFD2, PPP1R15A, SLC2A4, and WNT5B, with their expression levels corroborated using single-cell datasets, highlighting the potential therapeutic targets. To confirm the presence of these hub AAMRGs, real-time polymerase chain reaction and immunohistochemistry were employed. Results: We identified 2,115 DEGs between OA and control groups, with 1,062 upregulated and 1,053 downregulated. Enrichment analysis linked AAMRDEGs to amino acid catabolism and multiple KEGG pathways, indicating their importance in chondrocyte function and inflammation. Furthermore, significant correlations were observed between various immune cell types, underscoring the intricate role of the immune system in OA. Subsequently, we developed highly accurate diagnostic models using LASSO regression and SVM methodologies, achieving an area under the curve > 0.9. Protein-protein interaction analysis revealed significant interactions among Conclusion: This investigation presents a detailed evaluation of AAMRGs in OA, highlighting their roles in disease pathogenesis and offering new insights for therapeutic research. Key genes
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