ReviewInternational journal of general medicine2025
Infections in Moyamoya Phenomenon: Current Evidence and Future Horizons-Narrative Review.
Review in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moyamoya Disease (MMD) is a progressive cerebrovascular disorder characterized by the stenosis or occlusion of the terminal portions of the internal carotid arteries and fragile collateral vessel formation. While its etiology remains elusive, emerging evidence strongly implicates infections as key environmental triggers, particularly through immune-mediated vascular injury and interactions with genetic susceptibility (eg, RNF213 variants). This review explores the current understanding of the relationship between infections and MMD, examines epidemiological data, molecular and immunological mechanisms, genetic predispositions, and specific infections implicated in the disease. Critical limitations include causality ambiguity from reliance on anecdotal reports, methodological heterogeneity across studies, and mechanistic gaps in validating infection-endothelial dysfunction relationships. Future research must prioritize prospective cohorts and therapeutic strategies targeting infection-responsive pathways.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.