Evidence map›Paper›PMID 40727082›Full record

ArticleMaterials today. Bio2025

Collagen binding properties separate two functionally distinct subpopulations of milk extracellular vesicles regarding bone regenerative capacity.

Peng Wang, Yang Zhang, Onno J Arntz, Marina C Oliveira, Taozhao Yu, Zhihua Yang, Peter M van der Kraan, Jeroen J J P van den Beucken, Fons A J van de Loo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng WangDepartment of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Yang ZhangDepartment of Dentistry-Regenerative Biomaterials, Radboud University Medical Center, Nijmegen, the Netherlands.
Onno J ArntzDepartment of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Marina C OliveiraImmunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Taozhao YuSchool of Dentistry, Health Science Center, Shenzhen University, Shenzhen, China.
Zhihua YangSchool of Dentistry, Health Science Center, Shenzhen University, Shenzhen, China.
Peter M van der KraanDepartment of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.
Jeroen J J P van den BeuckenDepartment of Dentistry-Regenerative Biomaterials, Radboud University Medical Center, Nijmegen, the Netherlands.
Fons A J van de LooDepartment of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are heterogeneous in their composition. The proteins on their surface determine their binding properties to the meshwork of extracellular matrix (ECM). Here, we report that type I collagen-binding property separates two subpopulations of EVs from cow milk (mEVs): collagen-binding mEVs (

Indexed as

Bone defectsExtracellular matrixExtracellular vesiclesInteractome

Identifiers

PMID40727082
PMCPMC12302926

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.