ArticleQuantitative imaging in medicine and surgery2025
Association of magnetic resonance imaging glymphatic function with gray matter volume loss and cognitive impairment in Alzheimer's disease: a diffusion tensor image analysis along the perivascular space (DTI-ALPS) study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glymphatic dysfunction in Alzheimer's disease: a systematic review and meta-analysis of the DTI-ALPS index as an imaging biomarker.Frontiers in aging neuroscience · 2026Pooled it
- The role of glymphatic-related structural and functional imaging biomarkers in the pathological progression of Alzheimer's disease: a multimodal imaging-based study.Quantitative imaging in medicine and surgery · 2026Article
- Diffusion tensor image analysis along the perivascular space may serve as a potential biomarker for differentiating glioma recurrence from pseudoprogression: a preliminary study.Quantitative imaging in medicine and surgery · 2026Article
- Altered cerebrospinal fluid-based clearance mechanisms in aging autistic adults.Research square · 2026Article
- Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer's disease.Frontiers in neurologyArticle
- Diffusion tensor imaging along the perivascular space and choroid plexus volume for assessing the brain glymphatic system in overt hypothyroidism.Frontiers in neurologyArticle
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12 authors.
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Abstract
Background: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) has been used for diagnosing Alzheimer's disease (AD); however, few studies have examined the relationship between the DTI-ALPS index and cortical metrics, and the differentiation between AD severity levels remains unclear. This study aimed to explore the differences in DTI-ALPS index and cortex among AD patients with varying severities and to analyze the interactions between DTI-ALPS index, cortical metrics, and cognitive function. Methods: A total of 19 individuals with mild cognitive impairment (MCI), 17 individuals exhibiting mild AD, 25 individuals with moderate AD, and 28 healthy controls (HC) who were matched for age, sex, and education level were recruited. All the participants underwent diffusion tensor imaging (DTI) magnetic resonance imaging (MRI), followed by the calculation of the DTI-ALPS index to assess lymphatic system function. FreeSurfer (v7.4.1) was used to calculate thickness, volume, local gyre index, and area. One-way analysis of variance (ANOVA) was performed to compare the differences among HC, MCI, mild AD, and moderate AD groups. Pearson correlation analysis was employed to investigate the connection between the DTI-ALPS index and cognitive function, along with cortical metrics. Results: The HC, MCI, mild AD, and moderate AD groups exhibited significant differences in the DTI-ALPS index of the left hemisphere (P=0.008), whereas 13 cortical metrics revealed a statistical significance between groups (P<0.05). In the left hemisphere, the DTI-ALPS index showed a positive trend with the Montreal Cognitive Assessment (MoCA) score (r=0.397, P<0.001). Higher DTI-ALPS was also associated with an increase in 10 cortical metrics after controlling for age, sex, and education. Conclusions: There is a significant relationship between the DTI-ALPS index, cortical metrics, and cognitive function. This result may suggest that lymphatic dysfunction indicated by the DTI-ALPS index could mirror cortical structural degeneration and cognitive decline within the pathological process of AD. DTI-ALPS can be used as an indicator of structural degeneration and decline in cognitive function in AD.
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