ArticleQuantitative imaging in medicine and surgery2025
Accuracy and consistency of subtraction dual-layer spectral computed tomography in diagnosing coronary stenosis: invasive coronary angiography validation study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Dark-blood" Imaging in Coronary CT Angiography Using Dual layer Detector Spectral CT: Effect on Image Quality and Vessel Wall VisibilityCurrent medical imaging · 2026Article
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6 authors.
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Abstract
Background: Noninvasive assessment of coronary artery stenosis is critical for the diagnosis and management of coronary artery disease (CAD), particularly in patients with intermediate pretest probability for CAD or contraindications to invasive procedures. However, conventional coronary computed tomography angiography (CCTA Methods: Seventy-one consecutive patients with suspected or known CAD who underwent both CCTA and invasive coronary angiography (ICA) within 30 days participated in this study. Subtraction images were generated via the subtraction of virtual noncontrast datasets from 70-keV datasets of dual-layer spectral computed tomography (CT). Two independent radiologists evaluated the image quality and the conspicuity of the inner and outer vessel walls in subtraction images. ICA served as the gold standard for DS assessment. Interobserver agreement for subjective image quality was assessed using weighted kappa statistics. The diagnostic accuracy of CCTA Results: The study population comprised 45 males (mean age: 64.5±11.5 years) and 26 females (mean age: 67.8±9.6 years), with 62.1% having severe DS (≥50%) as confirmed by ICA. The subjective evaluation of subtraction images yielded high scores for image quality (2.8±1.8), inner vessel wall conspicuity (1.8±0.8), and outer vessel wall conspicuity (1.9±0.9). Radiologists' subjective scores showed good consistency (all kappa values ≥0.7). Compared to CCTA Conclusions: Subtraction images derived from dual-layer spectral CT improved the visualization of the coronary artery vessel wall and showed good agreement with ICA in assessing the DS of coronary arteries. The findings support the clinical utility of CCTA
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