SynthesisFrontiers in physiology2025
The modulatory role of short-chain fatty acids on peripheral circadian gene expression: a systematic review.
Synthesis in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The Co-Evolution of Sleep and Diet: Toward an Emerging Framework of Evolutionary Chrononutrition in Circadian-Metabolic Health.Nutrients · 2026Review
- A Chrono-Metabolic Approach to Mental Health: Current Perspectives on Circadian Rhythms, Gut Microbiota, and Microbial Metabolites in Mood Disorders.Metabolites · 2026Review
- The Gastro-Circadian Metabolic Axis: A Comprehensive Framework for Chronotherapy in Gastroenterology.Cureus · 2026Review
- Processed Diets and Food Additives Shape the Gut Microbiota and Chronic Disease Risk Across the Life Course-A Three-Layer Ecosystem Disruption Model (TLED) Model.Life (Basel, Switzerland) · 2026Review
- Integrated Multi-Omics Analysis Identifies PDK4 and ACOT1 as Metabolic Hub Genes Associated With Myocardial Fibrosis in Diabetic Cardiomyopathy.Journal of diabetes research · 2026Article
- Gut microbiota: An overlooked target in dyslipidemia management.World journal of gastroenterology · 2025Article
- The gut-brain-circadian axis in anxiety and depression: a critical review.Frontiers in psychiatry · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythm disruption significantly impacts health and causes a wide range of metabolic, cardiovascular, and psychiatric disorders. Changes in peripheral circadian clock expression are associated with the gut microbiome, particularly via the activity of short-chain fatty acids (SCFAs). The objective of this review is to explore the association between SCFA levels and peripheral circadian gene expression. This review was performed according to PRISMA guidelines. In total, eight studies were included after the PubMed database search and screening process based on inclusion and exclusion criteria. Risk of bias assessment was conducted using the SYRCLE and RoB 2 tools for animal and human studies, respectively. The results showed that propionate, acetate, and butyrate levels correlated with the expression of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.