ArticleFrontiers in medicine2025
Impact of temperature on EC
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of voltage-gated sodium channels on the median effective dose of ropivacaine in diabetic rats.Scientific reports · 2026Article
- Median Effective Concentration of Ropivacaine for Ultrasound-Guided TDrug design, development and therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The efficacy of local anesthetics like ropivacaine in axillary brachial plexus blocks may be influenced by temperature, though its impact on the median effective concentration (EC Methods: Fifty-nine patients scheduled for upper limb surgery under ultrasound-guided brachial plexus block with ropivacaine were randomly divided into the RT group or BT group, with ropivacaine stored at 23°C for the RT group and 37°C for the BT group. The ropivacaine concentration for each subsequent patient was determined using the up-and-down method. If the sensory nerve block met surgical incision requirements within 30 min, it was classified as "Effective"; otherwise, it was classified as "Ineffective." For "Effective" cases, the ropivacaine concentration was reduced by 0.05% for the next patient, while for "Ineffective" cases, it was increased by 0.05%. The initial ropivacaine concentration was set at 0.5% for both groups. Probit regression analysis was then used to determine the EC Results: The EC Conclusion: Warming ropivacaine to 37°C reduces the EC Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=28438 Identifier, ChiCTR1800016721.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.