ArticleFrontiers in nutrition2025
Clinical and computational exploration of red date fruit vinegar: synergistic effects on cardiovascular and type 2 diabetes pathways.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global research trends and hotspots of short-chain fatty acids in cognitive impairment: a bibliometric analysis based on two databases.Frontiers in medicine · 2026Pooled it
- Valorization of Date Palm (Molecules (Basel, Switzerland) · 2026Review
- Neuroprotective role ofFrontiers in nutrition · 2026Article
- Integrated metabolomic, proteomic, and transcriptomic analyses reveal the production of bioactive metabolites and antidiabetic effects in matureFrontiers in plant science · 2026Article
- Storage temperature and quality dynamics of sun-aged red date vinegar beverage.Frontiers in nutrition · 2026Article
- Sun-aged red date vinegar-based beverage: integrated analysis of fermentation, sensory, volatile, and bioactive properties.Food chemistry: X · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Dates (Phoenix dactylifera), often questioned for their high sugar content, may provide anti-diabetic benefits through their phytochemicals. Date vinegar offers a potentially effective alternative with reduced sugar content and enhanced bioactivity. This study evaluated the effects of date vinegar on glycemic control and lipid profiles in adults with type 2 diabetes mellitus (T2DM) and dyslipidemia while exploring the molecular mechanisms of its bioactive compounds in managing cardiovascular diseases (CVDs) and T2DM. Methods: A 10-week randomized controlled trial assessed the clinical effects of date vinegar. Complementary experiments explored therapeutic mechanisms through computational analysis and assessed sugar reduction and bioactive preservation under varying drying conditions. Fifty adults with T2DM and dyslipidemia were randomized into two groups: 25 participants received 20 mL of date vinegar daily, while 25 received a placebo. Clinical parameters were measured, including HbA1c, LDL cholesterol, and fasting blood sugar. Computational docking and molecular dynamics simulations investigated interactions of bioactive compounds with key protein targets. Results: Significant improvements were observed: HbA1c reduced from 6.85 to 6.08%, LDL cholesterol from 121.05 to 111.09 mg/dL, and fasting blood sugar from 168.4 to 147.6 mg/dL ( Conclusion: Date vinegar offers a dual target therapeutic strategy for managing T2DM and CVDs, supported by clinical and computational findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.