ArticleImmunity, inflammation and disease2025
Alleviative Effects of Ciprofol on Hepatic Ischemia/Reperfusion Injury Through Inhibiting Macrophage Polarization.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have demonstrated the protective role of ciprofol against ischemia/reperfusion (I/R) injury, with the present investigation focusing on elucidating its effects on hepatic I/R injury.
methodsA hepatic I/R injury animal model was established, and macrophages were polarized using lipopolysaccharide (LPS) induction. Hepatic tissue damage and apoptosis were assessed through hematoxylin-eosin and TUNEL staining. Liver function parameters, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as pro-inflammatory cytokine levels, were quantified using commercial assay kits. Macrophage polarization was evaluated via quantitative real-time PCR, immunofluorescence, and immunoblotting, with flow cytometry additionally employed to assess cellular polarization. Pro-inflammatory cytokine concentrations were also measured.
resultsIn the I/R model mice, ciprofol, comparable to the positive control propofol, and the macrophage eliminator gadolinium chloride (GdCl
conclusionThese findings suggest that ciprofol exerts hepatoprotective effects against I/R injury by modulating macrophage polarization.
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