Evidence map›Paper›PMID 40728518›Full record

ArticleAging2025

Co-regulation of Nr1d1 and Pparα in age-related changes of lipid metabolism and its modulation by calorie restriction.

Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim, Byung Pal Yu, Jeong-Hyun Yoon, Ki Wung Chung, Jaewon Lee, Hae Young Chung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sang Gyun NohResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Hyun Woo KimResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Seungwoo KimDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.
Byung Pal YuDepartment of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Jeong-Hyun YoonResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Ki Wung ChungResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Jaewon LeeResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Hae Young ChungResearch Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with a decline in liver function, which increases the risk of age-related metabolic disorders. Calorie restriction (CR) counteracts age-related changes in the liver; however, the underlying molecular mechanism remains elusive. In this study, we integrated transcriptomic, bioinformatic, and molecular analyses to investigate the effects of aging and CR on age-related gene expression in the rat liver, focusing on the interplay between the circadian rhythm and lipid metabolism. Our results revealed aging-induced upregulation of

Indexed as

AgingCaloric RestrictionLipid MetabolismLiverNuclear Receptor Subfamily 1, Group D, Member 1PPAR alphaAnimalsCircadian RhythmGene Expression RegulationMaleRatsNuclear Receptor Subfamily 1, Group D, Member 1PPAR alphaagingcalorie restrictionlipid metabolismNR1D1PPARα

Identifiers

PMID40728518
PMCPMC12339034

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.