Evidence map›Paper›PMID 40728601›Full record

ArticleJournal of materials science. Materials in medicine2025

An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects.

Jianzhong Bai, Dachuan Liu, Luguang Ding, Guoping Liu, Jiaying Li, Huan Wang, Li Dong, Chen Cui, Youzhi Hong, Shuangjian He and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jianzhong Bai *Department of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Dachuan Liu *Department of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Luguang DingDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Guoping LiuDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Jiaying LiDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Huan WangDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Li DongDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Chen CuiDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Youzhi HongDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China.
Shuangjian HeThe Affiliated Suzhou Hospital of Nanjing University Medical School, Suzhou, PR China. hsjian.ok@163.com.
Song ChenDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China. chensong@suda.edu.cn.ORCID http://orcid.org/0000-0002-5193-0369
Hongtao ZhangDepartment of Orthopedic Surgery, Medical 3D Printing Center, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, PR China. htzhangsz@126.com.

Funding

The National Key R&D Program of China 2023YFB3810200
6 · The paper itself

Abstract

The critical bone defect is a common clinical challenge worldwide, characterized by long recovery times, a substantial risk of infection, and high disability rates. There remains a significant demand for synthetic bone-repairing materials to address this issue. In this study, porous monetite was synthesized through the reaction between monocalcium phosphate monohydrate and β-tricalcium phosphate, using paraffin microspheres as pore-forming agents. An injectable biphasic cement was then developed by blending the monetite granules with hemihydrate calcium sulfate, designed for minimally invasive surgical applications. The cement demonstrated excellent biocompatibility and osteogenic properties in vitro. Furthermore, in vivo studies confirmed the cement's superior bone repair capabilities, indicating its promising potential for the treatment of critical bone defects.

Indexed as

Bone CementsCalcium PhosphatesCalcium SulfateSkullAnimalsBiocompatible MaterialsBone RegenerationBone SubstitutesHumansInjectionsMaterials TestingMiceOsteogenesisPorosityRabbitsBiocompatible MaterialsBone CementsBone SubstitutesCalcium PhosphatesCalcium Sulfate

Identifiers

PMID40728601
PMCPMC12307452

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.