Evidence map›Paper›PMID 40728977›Full record

ArticleCurrent issues in molecular biology2025

Validation of Prognostic Circulating Cell-Free RNA Biomarkers

Chau Ming Kan, Xiao Meng Pei, Simon Siu Man Ng, Wing Wa Leung, Yee Ni Wong, Hennie Yuk-Lin Cheng, William Chi Shing Cho, Hin Fung Tsang, Sze Chuen Cesar Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chau Ming KanDepartment of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Xiao Meng PeiDepartment of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Simon Siu Man NgDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wing Wa LeungDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Yee Ni WongDepartment of Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Hennie Yuk-Lin ChengDepartment of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China.
William Chi Shing ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China.ORCID 0000-0003-4174-4586
Hin Fung TsangDepartment of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Sze Chuen Cesar WongDepartment of Applied Biology & Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China.

Funding

Lim Peng Suan Charitable Trust Research Grants P0046023 and P0039295
6 · The paper itself

Abstract

Circulating cell-free RNAs (cfRNAs) have emerged as promising non-invasive biomarkers for colorectal cancer (CRC), offering insights into the disease's prognosis. This study investigates the prognostic significance of the specific cfRNA biomarkers

Indexed as

circulating cell-free RNAs (cfRNAs)colorectal cancer (CRC)HPGDminimal residual disease (MRD)PACS1prognostic biomarkersTaqman quantitative PCR (qPCR)TDP2

Identifiers

PMID40728977
PMCPMC12293443

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.