Evidence map›Paper›PMID 40728979›Full record

ArticleCurrent issues in molecular biology2025

CD63 Immunological Activation Versus Hemostatic Function: Platelet Alterations After Polytrauma.

Gregor Roemmermann, Olivia Bohe, Laura Heimann, Franziska Wirth, Franziska Drumm, Peter Biberthaler, Philipp Moog, Christina Schwenk, Nadja Muehlhaupt, Li Wan and 1 more

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gregor RoemmermannDepartment of Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0009-0009-0572-3068
Olivia BoheDepartment of Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0003-0227-4016
Laura HeimannExperimental Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Franziska WirthExperimental Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Franziska DrummExperimental Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Peter BiberthalerDepartment of Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Philipp MoogDepartment of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Christina SchwenkExperimental Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Nadja MuehlhauptExperimental Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Li WanExperimental Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Marc HanschenDepartment of Trauma Surgery, Klinikum Rechts der Isar, TUM University Hospital, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0002-2683-9870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelets are attributed an increasing role in the post-traumatic immune response. The exact mechanisms, particularly the link between immune response and hemostasis, have not been conclusively established. This study aimed to investigate the activity marker CD63 on platelets after polytrauma and its significance for hemostasis. A non-interventional, prospective clinical study was conducted, in which the blood of 20 polytraumatized patients was analyzed at nine time points within 10 days following trauma. Peripheral blood platelets were analyzed using flow cytometry to determine CD63 expression and rotational thromboelastometry (ROTEM

Indexed as

CD63hemostasisimmune responseplatelet activationplatelet functionpolytraumapost-traumatic coagulation disorders

Identifiers

PMID40728979
PMCPMC12294029

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.