Evidence map›Paper›PMID 40729255›Full record

ArticleReports (MDPI)2024

Coronary Artery Disease Is Related to Methylation Disorders Caused by the c.1286A>C

Agnieszka Pietruszyńska-Reszetarska, Robert Pietruszyński, Ireneusz Majsterek, Tomasz Popławski, Maciej Skrzypek, Beata Kolesińska, Joanna Waśko, Joanna Kapusta, Cezary Watała, Robert Irzmański

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reports (MDPI), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Agnieszka Pietruszyńska-ReszetarskaDepartment of Internal Medicine, Rehabilitation and Physical Medicine, Medical University of Lodz, 90-647 Lodz, Poland.ORCID 0000-0001-9194-7870
Robert PietruszyńskiCardiology Outpatient Clinic, Military Medical Academy Memorial Teaching Hospital, Medical University of Lodz-Central Veterans' Hospital, 90-549 Lodz, Poland.
Ireneusz MajsterekDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Tomasz PopławskiDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0003-2300-7339
Maciej SkrzypekDepartment of Clinical Chemistry and Biochemistry, Medical University of Lodz, 92-215 Lodz, Poland.
Beata KolesińskaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 90-924 Lodz, Poland.ORCID 0000-0002-4581-947X
Joanna WaśkoInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 90-924 Lodz, Poland.ORCID 0000-0002-5210-2290
Joanna KapustaDepartment of Internal Medicine, Rehabilitation and Physical Medicine, Medical University of Lodz, 90-647 Lodz, Poland.ORCID 0000-0002-5082-3641
Cezary WatałaDepartment of Hemostasis and Hemostatic Disorders, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-5627-7872
Robert IrzmańskiDepartment of Internal Medicine, Rehabilitation and Physical Medicine, Medical University of Lodz, 90-647 Lodz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSingle nucleotide polymorphisms in gene encoding is the key enzyme in the folates pathway, methyltetrahydrofolate reductase (MTHFR), which causes methylation disorders associated with coronary artery disease (CAD). We evaluated associations between methylation disorders caused by

methodsStudy group: 34 patients with CAD confirmed by invasive coronary angiography (ICA). CONTROLS: 14 patients without CAD symptoms or significant coronary artery stenosis, based on ICA or multislice computed tomography (MSCT) with coronary artery calcification (CAC) scoring. Real-time PCR genotyping was assessed using TaqMan™ probes. Folic acid and 5-MTHF concentrations in blood serum were determined using Liquid Chromatography-Mass Spectrometry (LC-MS).

resultsThe c.[1286A>C];[1286A>C]

conclusionsFurther studies on a larger scale are needed to implicate the homozygous c.1286A>C

Indexed as

5-MTHFbiomarkercoronary artery diseasefolic acidgene polymorphismmethylation

Identifiers

PMID40729255
PMCPMC12225410

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.