ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Dynamics of multimorbidity, health expectancy, and survival in middle aged and older individuals.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effect of aspirin on grip strength and gait speed in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly (ASPREE) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Trial
- Burden and Patterns of Oral Diseases and Systemic Comorbidities in Older Adults Attending Primary Care: A Sex- and Age-Stratified Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025.The Journal of frailty & aging · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundLife expectancy has increased, but such increase has disproportionally expanded the period of life with diseases. Whether expanding health expectancy (HE), defined as years of life free of chronic diseases, could also affect rate of multimorbidity accumulation is uncertain. Objective: to investigate the dynamic relationship between HE and rate of multimorbidity accumulation and their impact on survival.
methodsFour thousand two hundred seventy-four (3511 > 50 years) participants from the Health and Retirement Study (HRS), healthy at baseline and developing at least one disease overtime were included. Mean baseline age was 55.1 years and average follow-up was 9.4 years. Multimorbidity was operationalized as count of diagnosed diseases from a list of nine chronic conditions. HE was operationalized as years from birth until when the first disease was ascertained, and percentage of life in good health calculated as percentage of life lived free of chronic diseases. Mixed models investigated the association between HE and rate of multimorbidity accumulation, while survival analyses evaluated association with time to death.
resultsHE were positively associated with multimorbidity rate (P < .001). Shorter HE and faster multimorbidity rate were independently associated with higher mortality (P < .001). Their interaction was negatively associated with mortality (P < .001). Results were confirmed restricting the analysis to individuals 51 or older and using HRS specific weights. Individuals with longer HE experienced a greater survival, almost regardless of multimorbidity rate, while a positive gradient was found in percentage of life in good health linked to multimorbidity rate.
conclusionsExpanding health expectancy is likely followed by compression of morbidity.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.