ArticleCurrent protocols2025
Evaluating Neuropsychiatric Disease in Mouse Models of Systemic Lupus Erythematosus.
Article in Current protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human-relevant translation.Animal models and experimental medicine · 2026Review
- Estradiol Reverses Ovariectomy-Induced Small RNA-mRNA Stress Signatures to Restore Neuroendocrine, Synaptic, and Immune Homeostasis in the Hypothalamus.Biomolecules · 2026Article
- IFNγ-associated immune-metabolic remodeling is linked to serotonin-kynurenine imbalance and cortical vulnerability in lupus-prone mice.Frontiers in immunology · 2026Article
- Evaluating Neuropsychiatric Disease in Mouse Models of Systemic Lupus Erythematosus.Current protocols · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary neuropsychiatric manifestations in systemic lupus erythematosus (NPSLE) affect 20% to 40% of patients, significantly impacting quality of life and patient prognosis. However, the complex pathophysiology underlying these manifestations remains incompletely understood, partly due to challenges in distinguishing direct disease effects from secondary complications. Animal models are essential for investigating these mechanisms, but their effective utilization requires standardized behavioral assessment protocols, an area where the field currently lacks sufficient consensus. This article presents seven validated behavioral paradigms optimized for NPSLE mouse models, covering four key behavioral domains: activity levels (open field test); anxiety-like behavior (open field test, dark-light box, elevated plus maze); depression-like behavior (tail suspension test, Porsolt swim test); and cognitive function (novel objects, Barnes maze). We provide detailed protocols for each test, including equipment specifications, procedural steps, parameter measurements, and troubleshooting guidance specifically tailored for NPSLE research. Special considerations for NPSLE mouse models, including potential confounding factors like light sensitivity, motor impairments, and stress sensitivity, are addressed throughout. Additionally, we offer strategic recommendations for test selection based on specific research objectives, emphasizing the importance of test sequencing, proper habituation, and consistent handling techniques. We additionally recommend correlating behavioral outcomes with immunological markers to establish relationships between immune dysfunction and neuropsychiatric manifestations. By standardizing behavioral assessment methodologies in NPSLE research, these protocols enable more reliable cross-laboratory comparisons, enhance reproducibility, and ultimately improve translational relevance. The rigorous behavioral phenotyping approaches detailed herein will facilitate more accurate modeling of neuropsychiatric manifestations in lupus, advance our understanding of underlying disease mechanisms, and accelerate the development of targeted therapeutic interventions for this challenging aspect of SLE. © 2025 The Author(s). Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Open field test: Assessment of locomotor activity and anxiety-like behavior Basic Protocol 2: Novel object assays: Assessment of learning and memory Basic Protocol 3: Dark-light box: Assessment of anxiety-like behavior Basic Protocol 4: Elevated plus maze: Assessment of anxiety-like behavior Basic Protocol 5: Barnes maze: Assessment of spatial learning and memory Basic Protocol 6: Tail suspension test: Assessment of depression-like behavior Basic Protocol 7: Porsolt swim test: Assessment of depression-like behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.