Evidence map›Paper›PMID 40730502›Full record

Trial reportJournal of microbiology and biotechnology2025

Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers.

Ji-Won Seo, Jun-Hyun Bae, Ju Gyeong Kim, Su-Bin Bak, Gyoung-Deuck Kim, Wook Song

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ji-Won SeoHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Jun-Hyun BaeInstitute of Sports Science, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Ju Gyeong KimFood Science R&D Center, Kolmar BNH Co., Ltd, Seoul 30003, Republic of Korea.
Su-Bin BakFood Science R&D Center, Kolmar BNH Co., Ltd, Seoul 30003, Republic of Korea.
Gyoung-Deuck KimFood Science R&D Center, Kolmar BNH Co., Ltd, Seoul 30003, Republic of Korea.
Wook SongHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HemoHIM is a mixed extract derived from the roots of oriental medicinal herbs. Despite many studies on HemoHIM's antioxidant properties and its effect on immune functions, fatigue reduction, and exercise performance, published data regarding its physiological safety in humans are lacking. Therefore, this study aimed to investigate the safety profile of HemoHIM in humans. The samples were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with ultra-high-performance LC coupled to an Orbitrap MS. Data processing and compound identification were performed through nontargeted screening using multiple spectral databases. Ninety-six healthy adults were recruited in the clinical study. On visit 1, screening was conducted to assess eligibility. On visit 2, participants were randomly assigned to either the HemoHIM group (

Indexed as

Plant ExtractsAdultAntioxidantsBiomarkersChromatography, LiquidDietary SupplementsDouble-Blind MethodFemaleHealthy VolunteersHumansMaleMiddle AgedTandem Mass SpectrometryYoung AdultAntioxidantsBiomarkersPlant Extractsbioactive compoundsblood and urine testsHemoHIMLC-MS/MS analysissafety

Identifiers

PMID40730502
PMCPMC12324994

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.