Evidence map›Paper›PMID 40730932›Full record

ReviewMedical oncology (Northwood, London, England)2025

Targeting racial disparities in breast cancer: mechanistic insights and therapeutic potential of African medicinal plants.

Acharya Balkrishna, Sonam Verma, Sumit Kumar Singh, Vidhi Dobhal, Vedpriya Arya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Acharya BalkrishnaPatanjali Herbal Research Department, Patanjali Research Foundation, Haridwar, Uttarakhand, India.ORCID http://orcid.org/0000-0003-4749-6317
Sonam VermaPatanjali Herbal Research Department, Patanjali Research Foundation, Haridwar, Uttarakhand, India.ORCID http://orcid.org/0000-0002-6323-9284
Sumit Kumar SinghPatanjali Herbal Research Department, Patanjali Research Foundation, Haridwar, Uttarakhand, India. kumarsumit90@gmail.com.ORCID http://orcid.org/0000-0001-5941-111X
Vidhi DobhalPatanjali Herbal Research Department, Patanjali Research Foundation, Haridwar, Uttarakhand, India.ORCID http://orcid.org/0000-0001-9615-1345
Vedpriya AryaPatanjali Herbal Research Department, Patanjali Research Foundation, Haridwar, Uttarakhand, India.ORCID http://orcid.org/0000-0001-7562-1731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review examines the multifaceted disparities in breast cancer outcomes between African American and European American women, with a focus on molecular drivers, epigenetic determinants, and the therapeutic potential of African medicinal plants. It addresses three key questions: (1) What biological mechanisms underlie racial disparities in breast cancer aggressiveness and survival? (2) How do gene-environment interactions contribute to these disparities? (3) Can African medicinal plants offer targeted solutions for high-risk populations?. A non-systematic literature search was conducted across PubMed, Web of Science, and Scopus using keywords such as "breast cancer disparities," "African American women," "tumor microenvironment," "DNA methylation," and "African medicinal plants." English-language studies were prioritized, encompassing molecular oncology, epidemiology, and ethnopharmacology. Data were synthesized into thematic areas like biological mechanisms and plant-derived therapies. AA women exhibit distinct tumor biology, including hypermethylation of tumor suppressors (RARB, CDH13), gene mutations (TP53), and pro-inflammatory microenvironments with elevated cytokines (IL-6, CCL5). Social determinants like structural racism and healthcare access barriers exacerbate outcomes. African medicinal plants like Vernonia amygdalina (IC

Indexed as

Breast NeoplasmsPlants, MedicinalBlack or African AmericanFemaleHumansPhytotherapyTumor MicroenvironmentWhiteAfrican American womenAfrican medicinal plantsBreast cancer disparitiesDNA methylationTriple-negative breast cancerTumor microenvironment

Identifiers

PMID40730932

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.