Evidence map›Paper›PMID 40731025›Full record

GuidelineCritical care (London, England)2025

Use of extracorporeal membrane oxygenation in adult trauma patients with refractory acute cardiopulmonary failure: guideline from the Chinese society of extracorporeal life support 2025.

Hua Wang, Zhongran Cen, Xingxing Liu, Zhanguo Liu, Xiaotong Hou, Xiangdong Guan, Jianfeng Wu, Yimin Li, Yonghao Xu, Chengbin Zhou and 48 more

Abstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. ARDS management in trauma patients.Intensive care medicine · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors.

Hua Wang *Department of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhongran Cen *Department of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xingxing Liu *Department of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhanguo LiuDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China. zhguoliu@163.com.
Xiaotong HouDepartment of Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. xt.hou@ccmu.edu.cn.
Xiangdong GuanDepartment of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jianfeng WuDepartment of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yimin LiDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yonghao XuDepartment of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chengbin ZhouDepartment of anesthesiology, Guangdong Provincial People's Hospital, Guangzhou, China.
Zhiyong PengDepartment of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fachun ZhouDepartment of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tongwen SunDepartment of Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bingyu QinDepartment of Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Jiandong LinDepartment of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Lina ZhangDepartment of Critical Care Medicine, Xiangya Hospital of Central South University, Changsha, China.
Jinghui LiDepartment of Critical Care Medicine, Haikou People's Hospital, Haikou, China.
You ShangDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Songqiao LiuDepartment of Critical Care Medicine, Zhongda Hospital Southeast University, Nanjing, China.
Zhenhua ZengDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaowu WangCardiovascular Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Qunqing ChenThoracic Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yanwu GuoDepartment of Neurosurgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Changbiao PengDepartment of Medical Administration, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yang WangDepartment of Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Songjian LiOrthopedic Department, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Chunyao WangDepartment of Critical Care Medicine, Peking Union Medical College Hospital, Beijing, China.
Shulin XiangDepartment of Critical Care Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi, China.
Zhou ChengDepartment of anesthesiology, Zhongshan City People's Hospital, Guangdong, China.
Peihua CaoDepartment of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, China.
Jie JiangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yihao ChenDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Duoduo YuDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Wenzhan LiaoDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Ye LiaoDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xiaoqin ChengDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Limei ChenDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yuxuan HeDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Jie HeDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Qingling GuoDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zenghui YueDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Ke DengDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Ying TangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Bo HuangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Cuiping LiuDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Sheng PengDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Jing CaiDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yaru ZhuDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Kai WangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yangyang WangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Qianwen WangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Jingjing YangDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Maoyou ShichenDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhuo LiDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Manli GuoDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xueshan LuoDepartment of Critical Care Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Chinese Society of Extracorporeal Life Support (CSECLS)
Guangdong Province Restrictive Techniques (ECMO) Clinical Application Training Base

Funding

National Natural Science Foundation of China 82472176
6 · The paper itself

Abstract

backgroundAdult trauma patients with refractory acute cardiopulmonary failure suffer from high morbidity and mortality. In the past decade, a growing body of researches has shown survival benefits of extracorporeal membrane oxygenation (ECMO) in trauma patients who fail to respond to optimal damage control resuscitation (DCR), and there is an opportunity to formulate clinical practice guidelines to guide clinicians in implementing trauma ECMO at the bedside.

methodsThe Chinese Society of Extracorporeal Life Support (CSECLS) convened a domestic panel of interdisciplinary experts to develop this guideline, adhering to the principles of the World Health Organization (WHO) Manual for Guideline Development and the policy of conflict of interest. Clinical key questions pertaining to trauma ECMO use were informed from expert interviews and literature reviews, and formulated as PICO (Population/Intervention/Comparison/Outcome) format for literature retrieval of original studies supporting the question. Then, panelists were assigned to address specific clinical questions, synthesize evidence, formulate recommendations and determine their strength, following the Recommendations Assessment, Development and Evaluation (GRADE) framework. The guideline steering committee and stakeholders approved the final document.

resultsEleven recommendations regarding trauma ECMO use in adult patients were formulated, focusing on the following topics: (1) indications; (2) patient screening; (3) timing of initiation; (4) multidisciplinary approach; (5) trauma ECMO management; and (6) complication prevention. Supporting evidences are elaborated in detail, and expert opinions on clinical application and future research provided.

conclusionAlthough the quality of the body of evidence is low to very-low, most researches have shown that ECMO improves the survival of adult trauma patients with varied injury mechanisms. However, decision-making should consider the individual characteristics, benefits and potential harms, patients' values and preferences, and long-term outcomes.

Indexed as

Extracorporeal Membrane OxygenationHeart FailureWounds and InjuriesAdultChinaHumansReview Literature as TopicAdultEvidence-based medicineExtracorporeal membrane oxygenationWounds and injuries

Identifiers

PMID40731025
PMCPMC12308958

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.