Evidence map›Paper›PMID 40731089›Full record

ReviewNature medicine2025

Resilience and brain health in global populations.

Chinedu T Udeh-Momoh, Joaquin Migeot, Karen Blackmon, Michelle M Mielke, Margherita Melloni, Lynne Cox, Kristine Yaffe, Hernando Santamaria-Garcia, Yaakov Stern, Agustin Ibanez

Abstract readReview
In one paragraph

Review in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Trial
  2. Article
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  5. Article
  6. Article
  7. Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  15. Review
  16. Advancing brain health equity with Indigenous peoples: A critical imperative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  17. The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  18. Article
  19. Building brain resilience through brain capital.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  20. Expotype-phenotype resilience and multimodal aging clocks.Clinical and translational medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chinedu T Udeh-MomohDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Joaquin MigeotLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez (UAI), Santiago, Chile.
Karen BlackmonBrain and Mind Institute, Aga Khan University, Nairobi, Kenya.
Michelle M MielkeDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-7177-1185
Margherita MelloniLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez (UAI), Santiago, Chile.
Lynne CoxDepartment of Biochemistry, University of Oxford, Oxford, UK.
Kristine YaffeWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Hernando Santamaria-GarciaGlobal Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.
Yaakov SternDepartment of Neurology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez (UAI), Santiago, Chile. agustin.ibanez@gbhi.org.

Funding

Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Social epigenetics of Alzheimer's disease and related dementias in Latin American countriesR01AG082056 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Michael Jay Corley · 2024 to 2026
$3.6M
Circadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0M
NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG082056NIA NIH HHS R01 AG083799
6 · The paper itself

Abstract

Resilience is a multifaceted concept that spans biological, psychological and social domains, and is critical for population health-particularly brain health. While most existing research originates from the global north, there is an urgent need to explore resilience in the majority world settings, where unique biological, exposomal, economic and sociocultural factors shape health. In this Review, we highlight resilience as a key modifier of brain health outcomes. We explore the biological correlates of resilience and the influence of the exposome. We propose future synergistic integrations of exposome, cultural reserve, community resilience, allostasis and whole-body health principles to promote an inclusive perspective in diverse settings. This approach is particularly relevant for majority world contexts, where resource constraints and cultural diversity demand adaptive, scalable and context-sensitive strategies. We discuss measurement approaches and operationalization strategies and, finally, we identify key priorities for future research and policy strategies, with an emphasis on local relevance, equity and sustainability.

Indexed as

BrainResilience, PsychologicalGlobal HealthHumans

Identifiers

PMID40731089
PMCPMC13189249

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.