Evidence map›Paper›PMID 40731176›Full record

ReviewMolecular biology reports2025

The application of the CRISPR-Cas system in Klebsiella pneumoniae infections.

Yihan Wang, Ke Zhu, Yadong Wang, Ying Wang, Jie Xu, Yuan Li, Fang Liu, Jinzhao Long, Haiyan Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. CRISPR-based next-generation molecular diagnostics for bone infection.Frontiers in cell and developmental biology · 2026
    Review
  4. CRISPR/Cas diagnostics forFrontiers in bioengineering and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yihan WangDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Ke ZhuDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Yadong WangDepartment of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, 450016, China.
Ying WangDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Jie XuDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Yuan LiDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Fang LiuDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Jinzhao LongDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China.
Haiyan YangDepartment of Epidemiology, School of Public Health, Zhengzhou University, No. 100 of Science Avenue, Zhengzhou, 450001, China. yhy@zzu.edu.cn.

Funding

National Key Research and Development Project 2023YFC2605603National Natural Science Foundation of China 82273696
6 · The paper itself

Abstract

Klebsiella pneumoniae (Kp) is an important conditional pathogen that causes bacteremia, pneumonia, sepsis, urinary tract infections, and liver abscesses. The emergence of multidrug-resistant Kp, especially carbapenem-resistant Kp (CRKP), has become a major challenge to global public health. There is a need for early identification and diagnosis of Kp pathogens as well as precise treatment of Kp infections. The CRISPR-Cas (Clustered regularly interspaced short palindromic repeats and associated Cas proteins) system is an adaptive immune mechanism for bacteria. Studies have shown that the presence of the CRISPR-Cas system is negatively correlated with drug resistance in Kp strains, and CRISPR-Cas system-based technologies have been developed for the detection, gene editing, the development of therapeutic drugs and vaccines in Kp infections. However, no review has been published on this area; therefore, this review describes the role of the CRISPR-Cas system in the development of antibiotic resistance in Kp, the application of CRISPR-Cas system-based technology in detection and gene editing, and the therapeutic potential of CRISPR-Cas system in Kp infections.

Indexed as

CRISPR-Cas SystemsKlebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialGene EditingHumansAnti-Bacterial AgentsCRISPR/CasDetectionGene editingKlebsiella pneumoniaeVaccine development

Identifiers

PMID40731176

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.